Wu Hao, Li Yao-Lei, Liu Pan-Miao, Yang Jian-Jun
Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
National Institutes for Food and Drug Control, Beijing, China.
Front Aging Neurosci. 2025 Mar 11;17:1496252. doi: 10.3389/fnagi.2025.1496252. eCollection 2025.
Neurodegenerative diseases (NDs) are chronic and progressive conditions that significantly impact global public health. Recent years have highlighted exosomes as key mechanisms involved in these diseases. This study aims to visualize and analyze the structure and content of exosomes in NDs based on past research to identify new research ideas and directions. Through bibliometric analysis, we assess the current state of research on exosomes in the field of NDs worldwide over the past decade, highlighting significant findings, major research areas, and emerging trends.
Publications on exosomes in NDs research were obtained from the Web of Science Core Collection (WOSCC) database. Eligible literature was analyzed using Bibliometric R, VOSviewer, and Citespace.
Between 2014 and 2023, 2,393 publications on exosomes in NDs were included in the analysis. The number of relevant publications has been increasing yearly, with China leading in international collaboration, followed by the United States. And China has the largest number of academic scholars as leading and corresponding authors in all the countries, known as the great research society and community. Notable institutions contributing to these publications include , , and , which rank highly in both publication volume and citations. is a pivotal figure in the author collaboration network, having produced the highest number of publications (Sato et al., 2011) and amassed 3,921 citations. The journal with the most published articles in this field is , which has published 131 articles and received 3,347 citations. A recent analysis of keyword clusters indicates that "Exosome-like liposomes," "Independent mechanisms," and "Therapeutic potential" are emerging research hotspots.
This is the first bibliometric study to provide a comprehensive summary of the research trends and developments regarding exosomes in NDs studies. Future research in this area may explore the role of mesenchymal stromal cells, microRNAs (miRNAs), and targeted drug delivery systems to further investigate the underlying mechanisms and develop new therapeutics.
神经退行性疾病（NDs）是慢性进行性疾病，对全球公共卫生有重大影响。近年来，外泌体已成为这些疾病的关键机制。本研究旨在基于以往研究可视化和分析神经退行性疾病中外泌体的结构和内容，以确定新的研究思路和方向。通过文献计量分析，我们评估了过去十年全球神经退行性疾病领域外泌体研究的现状，突出了重要发现、主要研究领域和新兴趋势。
从科学网核心合集（WOSCC）数据库中获取神经退行性疾病研究中外泌体的出版物。使用文献计量R、VOSviewer和Citespace对符合条件的文献进行分析。
2014年至2023年期间，分析纳入了2393篇关于神经退行性疾病中外泌体的出版物。相关出版物数量一直在增加，中国在国际合作方面领先，其次是美国。在所有国家中，中国作为第一作者和通讯作者的学术学者数量最多，被誉为伟大的研究团体和社区。对这些出版物有突出贡献的机构包括 、 和 ，它们在出版物数量和引用次数方面都名列前茅。 在作者合作网络中是关键人物，发表的出版物数量最多（Sato等人，2011年），被引用3921次。该领域发表文章最多的期刊是 ，发表了131篇文章，被引用3347次。最近对关键词聚类的分析表明，“外泌体样脂质体”、“独立机制”和“治疗潜力”是新兴的研究热点。
这是第一项对神经退行性疾病研究中外泌体的研究趋势和发展进行全面总结的文献计量学研究。该领域未来的研究可能会探索间充质基质细胞、微小RNA（miRNAs）和靶向药物递送系统的作用，以进一步研究潜在机制并开发新的治疗方法。
