Marioni Gino, Zanoletti Elisabetta, Lovato Andrea, Franchella Sebastiano, Giacomelli Luciano, Gianatti Andrea, Mazzoni Antonio, Blandamura Stella, Martini Alessandro
Department of Neurosciences, Otolaryngology Section, University of Padova, Via Giustiniani 2, 35128, Padova, Italy.
DIMED, University of Padova, Padova, Italy.
Eur Arch Otorhinolaryngol. 2015 Nov;272(11):3225-32. doi: 10.1007/s00405-014-3383-x. Epub 2014 Nov 12.
Temporal bone squamous cell carcinoma (TBSCC) is an uncommon, aggressive malignancy with a significant local recurrence rate even in patients with postoperative pathology reports of free surgical margins. This raises the question of how "free" negative margins should be to be oncologically safe, especially in bone tissue. A potential role for relaxin-2 hormone in tumor-driven osteolysis has recently been reported. The aim of this study was to assess the prognostic role of relaxin-2 expression in TBSCC tissue specimens and pathologically negative bone margins. Relaxin-2 immunohistochemical expression was assessed in 25 consecutively operated TBSCC patients. Several pathological variables correlated with recurrence rate (pT stage, dura mater involvement), disease-free survival (DFS) (pT stage, pN status, grade, and dura mater involvement), and disease-specific survival (DSS) (pT stage, pN status, grade, and dura mater involvement). The recurrence rate, DFS, and DSS did not correlate with relaxin-2 expression in TBSCC specimens or pathologically negative bone margins. Although local recurrence in TBSCC could relate to neoplastic bone invasion not apparent on conventional pathological investigations, the present preliminary findings seem to rule out any role of relaxin-2 in mediating this local aggressiveness. Molecular mechanisms of TBSCC recurrence after curative treatment should be further investigated.
颞骨鳞状细胞癌（TBSCC）是一种罕见的侵袭性恶性肿瘤，即使术后病理报告显示手术切缘阴性，其局部复发率仍很高。这就提出了一个问题，即从肿瘤学角度来看，切缘“阴性”要达到何种程度才算安全，尤其是在骨组织中。最近有报道称松弛素 - 2激素在肿瘤驱动的骨溶解中可能发挥作用。本研究的目的是评估松弛素 - 2在TBSCC组织标本和病理阴性骨切缘中的预后作用。对25例连续接受手术的TBSCC患者的松弛素 - 2免疫组化表达进行了评估。几个病理变量与复发率（pT分期、硬脑膜受累情况）、无病生存期（DFS）（pT分期、pN状态、分级和硬脑膜受累情况）以及疾病特异性生存期（DSS）（pT分期、pN状态、分级和硬脑膜受累情况）相关。复发率、DFS和DSS与TBSCC标本或病理阴性骨切缘中的松弛素 - 2表达无关。尽管TBSCC的局部复发可能与传统病理检查中未发现的肿瘤性骨侵袭有关，但目前的初步研究结果似乎排除了松弛素 - 2在介导这种局部侵袭性方面的任何作用。TBSCC根治性治疗后复发的分子机制应进一步研究。
