Lovin Benjamin D, Gidley Paul W
Bobby R. Alford Department of Otolaryngology-Head and Neck Surgery Baylor College of Medicine Houston Texas.
Department of Head and Neck Surgery The University of Texas MD Anderson Cancer Center Houston Texas.
Laryngoscope Investig Otolaryngol. 2019 Nov 13;4(6):684-692. doi: 10.1002/lio2.330. eCollection 2019 Dec.
The rarity of temporal bone squamous cell carcinoma (TBSCC) precludes a clear understanding of the disease and approach to its management. This review provides general background on the disease and discusses the current and emerging oncologic and rehabilitative management options.
PubMed literature review.
A review of the current literature was conducted to assess and collate up-to-date information regarding TBSCC management.
TBSCC is a rare and aggressive disease arising in the ear canal, temporal bone, or extratemporal sites. Prior radiation, chronic ear disease, or habitual ear picking may contribute to primary disease development. Because the symptoms of TBSCC and benign otologic disease are similar, TBSCC diagnosis may be delayed, allowing the tumor time to spread throughout the anatomically intricate temporal bone. The extent of the disease is determined based on imaging and is usually staged with the Pittsburgh Staging System. Temporal bone resection with parotidectomy and neck dissection is the current standard of care. Survival is generally good for early disease and poor for advanced disease, but chemotherapy is emerging as a promising treatment option. Auditory rehabilitation with osseointegrated hearing aids is recommended at initial oncologic resection.
The knowledge of and outcomes for TBSCC have improved with time, but because of the aggressive nature of the disease and the anatomic intricacy of the temporal bone, TBSCC treatment is complex and should be delivered by a multidisciplinary team. Inter-institutional collaboration may accelerate research for this rare disease.
颞骨鳞状细胞癌（TBSCC）较为罕见，这使得人们对该疾病及其治疗方法缺乏清晰的认识。本综述提供了该疾病的一般背景信息，并讨论了当前及新兴的肿瘤学和康复治疗选择。
PubMed文献综述。
对当前文献进行综述，以评估和整理有关TBSCC治疗的最新信息。
TBSCC是一种罕见且侵袭性强的疾病，发生于耳道、颞骨或颞骨外部位。既往放疗、慢性耳部疾病或习惯性掏耳可能促使原发性疾病的发生。由于TBSCC的症状与良性耳部疾病相似，TBSCC的诊断可能会延迟，从而使肿瘤有时间在解剖结构复杂的颞骨中扩散。根据影像学确定疾病范围，通常采用匹兹堡分期系统进行分期。目前的标准治疗方法是颞骨切除联合腮腺切除及颈部淋巴结清扫术。早期疾病的生存率一般较好，晚期疾病的生存率较差，但化疗正成为一种有前景的治疗选择。建议在初次肿瘤切除时使用骨锚式助听器进行听觉康复。
随着时间的推移，人们对TBSCC的认识和治疗效果有所改善，但由于该疾病的侵袭性以及颞骨解剖结构的复杂性，TBSCC的治疗较为复杂，应由多学科团队进行。机构间合作可能会加速对这种罕见疾病的研究。
5级。
