早期血液灌流联合连续性静脉-静脉血液滤过可提高急性百草枯中毒患者的生存率。
Early haemoperfusion with continuous venovenous haemofiltration improves survival of acute paraquat-poisoned patients.
作者信息
Gao Yanxia, Zhang Xiaofan, Yang Yanjie, Li Wenlu
机构信息
Emergency Department, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Department of Stomatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
出版信息
J Int Med Res. 2015 Feb;43(1):26-32. doi: 10.1177/0300060514549782. Epub 2014 Nov 12.
OBJECTIVE
To determine whether haemoperfusion (HP) with continuous venovenous haemofiltration (CVVH) improves the survival of patients with acute paraquat poisoning, compared with those treated using HP alone.
METHODS
Medical records of patients with acute paraquat poisoning were analysed. Patients were randomised to undergo HP or HP + CVVH within 24 h of paraquat ingestion. Mortality rate, survival duration and cause of death were recorded.
RESULTS
There were no significant differences in mortality rate between the HP group (n = 458) and the HP + CVVH group (n = 226) (57.4% and 58.4%, respectively). The mean survival duration was significantly longer in the HP + CVVH group than the HP group (8.6 ± 3.1 and 5.1 ± 2.3 days, respectively). Early circulatory collapse was a major cause of death in the HP group. The major cause of death in the HP + CVVH group was late respiratory failure.
CONCLUSION
Combined therapy with HP and CVVH can prevent early death and prolong survival duration following acute paraquat poisoning, providing the opportunity for further treatment.
目的
与单独使用血液灌流（HP）治疗的患者相比，确定连续性静脉-静脉血液滤过（CVVH）联合HP是否能提高急性百草枯中毒患者的生存率。
方法
分析急性百草枯中毒患者的病历。患者在摄入百草枯后24小时内被随机分配接受HP或HP + CVVH治疗。记录死亡率、生存时间和死亡原因。
结果
HP组（n = 458）和HP + CVVH组（n = 226）的死亡率无显著差异（分别为57.4%和58.4%）。HP + CVVH组的平均生存时间明显长于HP组（分别为8.6±3.1天和5.1±2.3天）。早期循环衰竭是HP组的主要死亡原因。HP + CVVH组的主要死亡原因是晚期呼吸衰竭。
结论
HP与CVVH联合治疗可预防急性百草枯中毒后的早期死亡并延长生存时间，为进一步治疗提供机会。
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