Nasr Isfahani Sheida, Farajzadegan Ziba, Sabzghabaee Ali Mohammad, Rahimi Alireza, Samasamshariat Shiva, Eizadi-Mood Nastaran
Department of Clinical Toxicology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Social Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
J Res Med Sci. 2019 Jan 31;24:2. doi: 10.4103/jrms.JRMS_478_18. eCollection 2019.
Paraquat (PQ) poisoning is a serious public health problem in many countries. In spite of different treatments, the mortality is still high. We performed a meta-analysis to see whether hemoperfusion (HP) in combination with other treatments reduces the mortality more than HP alone in patients with PQ poisoning.
We searched EMBASE, PubMed, Google Scholar, ISI Web of Knowledge, Cochrane Central Register of Controlled Trials, Scopus, Springer, TRIP, ProQuest, and references of the included studies from January 2000 to August 2017. Two reviewers independently searched and extracted data. We measured to determine variance contributed by heterogeneity. To investigate the publication bias, Begg's and Egger's tests were used along with funnel plot analysis.
Ultimately 12 articles were included in the meta-analysis. Five articles compared HP with conventional therapy with a total of 1311 patients, and seven articles compared mortality of patients received HP versus those received HP in combination with an additional treatment. HP alone reduced the odds of death (odds ratio [OR] = 0.20; 95% confidence interval [CI]: 0.11-0.40, < 0.0001) compared to conventional therapy. Furthermore, the odds of death was higher in HP group compared to those received HP in combination of additional treatments (OR = 1.24; 95% CI: 1.05-1.46, = 0.01).
The mortality was less in HP-treated group compared to those received only conventional therapy. Addition of other treatments with HP reduced the mortality more than HP alone.
百草枯（PQ）中毒在许多国家都是严重的公共卫生问题。尽管有不同的治疗方法，但死亡率仍然很高。我们进行了一项荟萃分析，以观察血液灌流（HP）联合其他治疗方法在PQ中毒患者中是否比单独使用HP更能降低死亡率。
我们检索了EMBASE、PubMed、谷歌学术、ISI科学网、Cochrane对照试验中心注册库、Scopus、施普林格、TRIP、ProQuest以及2000年1月至2017年8月纳入研究的参考文献。两名评审员独立检索并提取数据。我们测量了 以确定异质性导致的方差。为了调查发表偏倚，使用了Begg检验和Egger检验以及漏斗图分析。
最终12篇文章纳入荟萃分析。5篇文章比较了HP与传统疗法，共有1311例患者，7篇文章比较了接受HP治疗的患者与接受HP联合其他治疗的患者的死亡率。与传统疗法相比，单独使用HP降低了死亡几率（优势比[OR]=0.20；95%置信区间[CI]：0.11 - 0.40，<0.0001）。此外，与接受HP联合其他治疗的患者相比，HP组的死亡几率更高（OR = 1.24；95% CI：1.05 - 1.46，=0.01）。
与仅接受传统疗法的患者相比，HP治疗组的死亡率更低。HP联合其他治疗比单独使用HP更能降低死亡率。
