Rao Raghavendra, Bhat Rama, Pathadka Swathi, Chenji Sravan Kumar, Dsouza Savio
Assistant Professor, Department of Medicine, Kasturba Medical College, Manipal University , Manipal, Karnataka, India .
Professor, Department of Medicine, Kasturba Medical College, Manipal University , Manipal, Karnataka, India .
J Clin Diagn Res. 2017 Feb;11(2):OC06-OC08. doi: 10.7860/JCDR/2017/24764.9166. Epub 2017 Feb 1.
Paraquat is a commonly ingested poison especially in Southern India. There is no antidote for paraquat poison and consumption is often fatal. The usual cause of death is either acute lung injury or multi-organ failure.
To evaluate the role of early haemoperfusion as a therapy in paraquat poisoned patients.
This study was a retrospective analysis of patients admitted to a Tertiary Medical College Hospital between January 2012 and December 2015 with history of paraquat consumption, comparing outcomes in those who received only gastric lavage and symptomatic treatment with those who received haemoperfusion as a therapy. The role of early haemoperfusion (≤ 6 hours) vs late haemoperfusion (> 6 hours) in paraquat poisoned patients was also compared. The data of these patients was extracted and analysed with respect to age, sex, mode of treatment, the outcome in patients who received early and late haemoperfusion.
A total of 101 patients were studied out of which 62 died. Deaths were more in those patients who received only gastric lavage with symptomatic treatment as therapy compared to those who received haemoperfusion i.e., 92.1% vs 42.9% respectively. We also found that, the survival rate was better in patients who received early haemoperfusion.
Early haemoperfusion was helpful in the management of severe paraquat poisoning and improved the survival rate in these patients.
百草枯是一种常见的经口摄入的毒物，在印度南部尤为常见。百草枯中毒没有解毒剂，摄入后往往会致命。通常的死亡原因是急性肺损伤或多器官功能衰竭。
评估早期血液灌流作为百草枯中毒患者治疗方法的作用。
本研究是对2012年1月至2015年12月期间入住三级医学院附属医院且有百草枯摄入史的患者进行的回顾性分析，比较仅接受洗胃和对症治疗的患者与接受血液灌流治疗的患者的结局。还比较了早期血液灌流（≤6小时）与晚期血液灌流（>6小时）对百草枯中毒患者的作用。提取并分析了这些患者的年龄、性别、治疗方式、接受早期和晚期血液灌流患者的结局等数据。
共研究了101例患者，其中62例死亡。仅接受洗胃和对症治疗的患者死亡率高于接受血液灌流的患者，分别为92.1%和42.9%。我们还发现，接受早期血液灌流的患者生存率更高。
早期血液灌流有助于严重百草枯中毒的治疗，并提高这些患者的生存率。
