Juang J K, Huang H W, Chen C M, Liu H J
Institute of Life Science and National Tsing Hua University, Taiwan, R.O.C.
Biochem Biophys Res Commun. 1989 Mar 31;159(3):1128-34. doi: 10.1016/0006-291x(89)92226-2.
Withangulatin A, a new compound with a known chemical structure and from the antitumor Chinese herb Physalis angulata L, was found to act on topoisomerase II to induce topoisomerase II-mediated DNA damage in vitro. It has two effective dosage ranges of approximate 0.5 and 20 microM, with about one-third the activity of 20 microM VM-26.
从抗肿瘤中草药酸浆中发现的具有已知化学结构的新化合物酸浆苦味素A，在体外作用于拓扑异构酶II以诱导拓扑异构酶II介导的DNA损伤。它有两个有效剂量范围，约为0.5和20微摩尔，其活性约为20微摩尔VM - 26的三分之一。
