Pannacciulli I M, Lerza R A, Bogliolo G V, Mencoboni M P, Saviane A G
Patologia Speciale Medica B, Istituto Scientifico di Medicina Interna, University of Genoa, Italy.
Br J Cancer. 1989 Mar;59(3):371-4. doi: 10.1038/bjc.1989.74.
DBA/2NCr1BR F1 mice received a single i.v. injection of doxorubicin (4.32, 7.20 or 12.00 mg kg-1), cyclophosphamide (70, 120 or 200 mg kg-1) or cis-diamminechloroplatinum (5.4, 9.0 or 15.0 mg kg-1), alone or 2 h before an i.p. injection of 1,000 mg kg-1 of diethyldithiocarbamate (DDTC). Twenty-four hours after, survival of bone marrow colony forming units-spleen and granulocyte-macrophage colony forming cells, was determined. On the whole, administration of DDTC reduced the toxic effect of the three anticancer drugs on haemopoietic progenitors. The effect was in general more evident at the lower than at the higher doses of the antitumour drugs.
DBA/2NCr1BR F1小鼠静脉注射一次阿霉素（4.32、7.20或12.00毫克/千克）、环磷酰胺（70、120或200毫克/千克）或顺二氯二氨铂（5.4、9.0或15.0毫克/千克），单独注射或在腹腔注射1000毫克/千克二乙二硫代氨基甲酸盐（DDTC）前2小时注射。24小时后，测定骨髓集落形成单位-脾脏和粒细胞-巨噬细胞集落形成细胞的存活率。总体而言，DDTC的给药降低了三种抗癌药物对造血祖细胞的毒性作用。一般来说，在较低剂量而非较高剂量的抗肿瘤药物作用下，这种效果更明显。
