Lerza R, Bogliolo G, Mencoboni M, Saviane A, Pannacciulli I
Cattedra di Patologia Speciale Medica B, Università di Genova, Italy.
Tumori. 1988 Jun 30;74(3):333-7. doi: 10.1177/030089168807400316.
The possible protective action of sodium-2-mercaptoethanesulfonate (mesna) on hemotoxicity induced by anticancer drugs was tested in normal mice. Mesna (100 mg/kg b.w.) was injected i.v. 1 h before the i.v. administration of cyclophosphamide (10, 120, and 200 mg/kg b.w.), doxorubicin (4.32, 7.2, and 12 mg/kg b.w.) and cis-diamminedichloroplatinum (5.4, 9, and 15 mg/kg b.w.). Results show that in this experimental model mesna does not seem to protect against toxicity of the tested anticancer drug on hemopoietic progenitor cells.
在正常小鼠中测试了2-巯基乙烷磺酸钠（美司钠）对抗癌药物诱导的血液毒性的可能保护作用。在静脉注射环磷酰胺（10、120和200mg/kg体重）、阿霉素（4.32、7.2和12mg/kg体重）和顺二氯二氨铂（5.4、9和15mg/kg体重）前1小时，静脉注射美司钠（100mg/kg体重）。结果表明，在该实验模型中，美司钠似乎不能保护造血祖细胞免受所测试抗癌药物的毒性作用。
