Rolston R K, Ghatei M A, Mulderry P K, Bloom S R
Department of Medicine, Royal Postgraduate Medical School, London, U.K.
Dig Dis Sci. 1989 Apr;34(4):612-6. doi: 10.1007/BF01536340.
We have studied the effect of exogenous calcitonin gene-related peptide on net fluxes of water and electrolytes in the rat small and large intestine. In ligated intestinal loops, intravenous calcitonin gene-related peptide (CGRP) induced colonic fluid secretion but had no effect on the small intestine. Subsequently, using a single-pass perfusion technique, we observed an immediate dose-dependent secretion of water by the rat colon upon intravenous administration of CGRP. Net secretion of sodium, potassium, and chloride were also raised. The implications of these observations for the possible involvement of high circulation concentrations of CGRP in the watery diarrhea syndrome accompanying medullary thyroid carcinoma are discussed.
我们研究了外源性降钙素基因相关肽对大鼠小肠和大肠水及电解质净通量的影响。在结扎的肠袢中，静脉注射降钙素基因相关肽（CGRP）可诱导结肠液分泌，但对小肠无影响。随后，采用单通道灌注技术，我们观察到静脉注射CGRP后，大鼠结肠立即出现剂量依赖性的水分泌。钠、钾和氯的净分泌也增加。讨论了这些观察结果对于高循环浓度的CGRP可能参与甲状腺髓样癌伴发的水样腹泻综合征的意义。
