[以脑软化症患者尿胃蛋白酶活性作为下丘脑 - 垂体 - 肾上腺轴活性指标的研究]
[Urinary uropepsin activity in patients with encephalomalacia as an index of the activity of the hypothalamo- hypophyseal-adrenal axis].
作者信息
Semczuk W
出版信息
Neurol Neurochir Pol. 1979 Jan-Feb;13(1):17-21.
PMID:253934
Abstract
The determinations were carried out in 25 patients with thrombotic encephalomalacia. The changes in 24-hour urine uropepsin activity were studied after administration of metopirone and dexamethasone. The uropepsin activity in a sample of 24-hour urine was determined by the method of West, Ellis and Scott. A statistically significant fall of uropepsin activity was observed in 24-hour urine after metopirone, with a rise in the activity of this enzyme after dexamethasone administration.
摘要
对25例血栓性脑软化患者进行了测定。研究了给予美替拉酮和地塞米松后24小时尿胃蛋白酶原活性的变化。采用韦斯特、埃利斯和斯科特的方法测定24小时尿样中的胃蛋白酶原活性。服用美替拉酮后，24小时尿中胃蛋白酶原活性出现统计学上的显著下降，而给予地塞米松后该酶的活性则升高。
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