宫颈活检标本组织病理学报告中的观察者变异性。
Observer variability in histopathological reporting of cervical biopsy specimens.
作者信息
Robertson A J, Anderson J M, Beck J S, Burnett R A, Howatson S R, Lee F D, Lessells A M, McLaren K M, Moss S M, Simpson J G
机构信息
Department of Pathology, Ninewells Hospital and Medical School, Dundee, Scotland.
出版信息
J Clin Pathol. 1989 Mar;42(3):231-8. doi: 10.1136/jcp.42.3.231.
Abstract
Sections from 100 cervical biopsy specimens were studied by 12 consultant histopathologists to determine the robustness of the existing pathology terminology and classification. Analysis by kappa statistics showed good agreement in the diagnosis of CIN 3 and squamous carcinoma but an inability to distinguish accurately between the lesser grades of CIN. It is recommended that the classification be changed to low grade (present CIN 1 and 2) and high grade (present CIN 3) categories alone. There was very poor agreement in the identification of cellular changes associated with human papilloma virus (HPV) infection.
摘要
12位顾问组织病理学家研究了100份宫颈活检标本的切片，以确定现有病理学术语和分类的稳健性。kappa统计分析表明，在诊断CIN 3和鳞状细胞癌方面具有良好的一致性，但无法准确区分较低级别的CIN。建议仅将分类改为低级别（现有的CIN 1和2）和高级别（现有的CIN 3）类别。在识别与人类乳头瘤病毒（HPV）感染相关的细胞变化方面，一致性非常差。
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