Koshi S, Egami T, Isogai M, Miyauchi Y
First Department of Surgery, Kumamoto University Medical School, Japan.
Nihon Geka Gakkai Zasshi. 1989 Jan;90(1):127-9.
Two cases of breast cancer associated with pregnancy were reported and the immunological assessment was performed in the second case. Case 1: A 36 year-old woman in the first trimester of pregnancy and having a large axillary mass and breast lump was admitted. She was diagnosed as having Stage IIIb breast cancer. After interruption of pregnancy, she received an extended radical mastectomy and radiotherapy. However, she died nine months after surgery for brain and liver metastases. Case 2: A 30 year-old woman in her second trimester of pregnancy was admitted for a large breast mass. She was diagnosed as having Stage IIIa breast cancer. Interruption of pregnancy was again necessary to perform surgery followed by chemotherapy. After an extended radical mastectomy she was placed on a combination chemotherapy regimen with cyclophosphamide, adriamycin and 5-FU. In both cases tumors began to develop rapidly at pregnancy. Immunological studies in Case 2 showed a depression of T-lymphocyte function and NK cell activity. Our study suggests that the depression of cell-mediated immunity during pregnancy may promote tumor growth.
报告了两例与妊娠相关的乳腺癌病例，并对第二例进行了免疫评估。病例1：一名36岁处于妊娠早期的女性，因腋窝有巨大肿块和乳房肿块入院。她被诊断为IIIb期乳腺癌。妊娠终止后，她接受了扩大根治性乳房切除术和放疗。然而，她在术后九个月因脑和肝转移死亡。病例2：一名30岁处于妊娠中期的女性因乳房巨大肿块入院。她被诊断为IIIa期乳腺癌。同样需要终止妊娠以进行手术，随后进行化疗。在扩大根治性乳房切除术后，她接受了环磷酰胺、阿霉素和5-氟尿嘧啶的联合化疗方案。在这两个病例中，肿瘤在妊娠期间开始迅速发展。病例2的免疫学研究显示T淋巴细胞功能和NK细胞活性降低。我们的研究表明，妊娠期间细胞介导免疫的降低可能促进肿瘤生长。
