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己酮可可碱及其在皮肤科的应用。

Pentoxifylline and its applications in dermatology.

作者信息

Hassan Iffat, Dorjay Konchok, Anwar Parvaiz

机构信息

Department of Dermatology, STD and Leprosy, Government Medical College Srinagar, University of Kashmir, Jammu and Kashmir, India.

出版信息

Indian Dermatol Online J. 2014 Oct;5(4):510-6. doi: 10.4103/2229-5178.142528.

DOI:10.4103/2229-5178.142528
PMID:25396144
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4228656/
Abstract

Pentoxifylline is a methyl-xanthine derivative with many anti inflammatory effects. Pentoxifylline has been found to be effective for many dermatological as well as non-dermatological conditions. It has been used both as primary drug as well as adjuvant and is a safe and relatively cost-effective alternative drug. In this article, we review the literature and highlight various important aspects of pentoxifylline.

摘要

己酮可可碱是一种具有多种抗炎作用的甲基黄嘌呤衍生物。已发现己酮可可碱对许多皮肤病学和非皮肤病学病症均有效。它既用作主要药物,也用作辅助药物,是一种安全且相对具有成本效益的替代药物。在本文中,我们回顾了相关文献并强调了己酮可可碱的各个重要方面。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f865/4228656/6854f61879b6/IDOJ-5-510-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f865/4228656/6854f61879b6/IDOJ-5-510-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f865/4228656/6854f61879b6/IDOJ-5-510-g001.jpg

相似文献

1
Pentoxifylline and its applications in dermatology.己酮可可碱及其在皮肤科的应用。
Indian Dermatol Online J. 2014 Oct;5(4):510-6. doi: 10.4103/2229-5178.142528.
2
Pentoxifylline in dermatology.己酮可可碱在皮肤科的应用。
J Cosmet Dermatol. 2023 Feb;22(2):410-417. doi: 10.1111/jocd.15445. Epub 2022 Oct 31.
3
Pentoxifylline use in dermatology.己酮可可碱在皮肤科的应用。
Inflamm Allergy Drug Targets. 2012 Dec;11(6):422-32. doi: 10.2174/187152812803590028.
4
The xanthine derivative 1-(5'-oxohexyl)-3-methyl-7-propyl xanthine (HWA 285) enhances the actions of adenosine.
Acta Pharmacol Toxicol (Copenh). 1986 Mar;58(3):187-92. doi: 10.1111/j.1600-0773.1986.tb00093.x.
5
Pentoxifylline, a methyl xanthine derivative, reduces peritoneal adhesions and increases peritoneal fibrinolysis in rats.己酮可可碱,一种甲基黄嘌呤衍生物,可减少大鼠腹膜粘连并增强其腹膜纤维蛋白溶解作用。
Tohoku J Exp Med. 2006 Jul;209(3):249-55. doi: 10.1620/tjem.209.249.
6
Pentoxifylline: a drug with wide spectrum applications in dermatology.己酮可可碱:一种在皮肤科有广泛应用的药物。
Dermatol Online J. 2008 Nov 15;14(11):2.
7
A fatal case of suicidal pentoxifylline intoxication.
Int J Legal Med. 1998;111(3):151-3. doi: 10.1007/s004140050136.
8
Urinary excretion of pentoxifylline and its metabolites by standardbred mares.标准赛马母马对己酮可可碱及其代谢物的尿排泄情况。
Can J Vet Res. 1989 Apr;53(2):147-53.
9
Prolongation of pentoxifylline aliphatic side chain positively affects the reversal of P-glycoprotein-mediated multidrug resistance in L1210/VCR line cells.己酮可可碱脂肪族侧链的延长对P-糖蛋白介导的L1210/VCR细胞系多药耐药性的逆转产生积极影响。
Gen Physiol Biophys. 2005 Dec;24(4):461-6.
10
Pentoxifylline for neonatal sepsis.己酮可可碱用于新生儿败血症
Cochrane Database Syst Rev. 2003(4):CD004205. doi: 10.1002/14651858.CD004205.

引用本文的文献

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African Medicinal Plants in Cutaneous Wound Repair: A Comprehensive Analysis of the Role of Phytochemicals.用于皮肤伤口修复的非洲药用植物:植物化学物质作用的综合分析
Int Wound J. 2025 Aug;22(8):e70742. doi: 10.1111/iwj.70742.
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Exploring pentoxifylline as an alternative treatment for dexamethasone in diabetic patients with COVID-19: a randomized controlled trial.探索己酮可可碱作为2型糖尿病合并COVID-19患者地塞米松替代治疗的疗效:一项随机对照试验。
Eur J Med Res. 2025 Jul 1;30(1):540. doi: 10.1186/s40001-025-02678-1.
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Niosome as a promising tool for increasing the effectiveness of anti-inflammatory compounds.

本文引用的文献

1
Venous ulcers of the lower limb: Where do we stand?下肢静脉溃疡:我们目前的状况如何?
Indian J Plast Surg. 2012 May;45(2):266-74. doi: 10.4103/0970-0358.101294.
2
Lipodermatosclerosis: improvement noted with hydroxychloroquine and pentoxifylline.脂膜炎性硬化症:使用羟氯喹和己酮可可碱后症状改善。
J Am Acad Dermatol. 2012 Jun;66(6):1013-4. doi: 10.1016/j.jaad.2011.11.942.
3
Pentoxifylline therapy in the management of oral submucous fibrosis.己酮可可碱疗法在口腔黏膜下纤维化治疗中的应用
脂质体作为一种提高抗炎化合物有效性的有前景的工具。
EXCLI J. 2024 Feb 7;23:212-263. doi: 10.17179/excli2023-6868. eCollection 2024.
4
Intralesional Pentoxifylline Injection Versus Triamcinolone Acetonide in Treating localized Alopecia Areata: A Comparative Study.病灶内注射己酮可可碱与曲安奈德治疗局限性斑秃的对比研究
J Clin Aesthet Dermatol. 2023 Nov;16(11):26-30.
5
Pentoxifylline/Chitosan Films on Wound Healing: In Vitro/In Vivo Evaluation.己酮可可碱/壳聚糖薄膜对伤口愈合的影响:体内外评价
Pharmaceutics. 2023 Mar 31;15(4):1122. doi: 10.3390/pharmaceutics15041122.
6
Current Insights and Molecular Docking Studies of the Drugs under Clinical Trial as RdRp Inhibitors in COVID-19 Treatment.在 COVID-19 治疗中作为 RdRp 抑制剂处于临床试验阶段的药物的最新研究进展和分子对接研究。
Curr Pharm Des. 2022;28(46):3677-3705. doi: 10.2174/1381612829666221107123841.
7
Therapeutic Potential of the Combination of Pentoxifylline and Vitamin-E in Inflammatory Bowel Disease: Inhibition of Intestinal Fibrosis.己酮可可碱与维生素E联合应用于炎症性肠病的治疗潜力:抑制肠道纤维化
J Clin Med. 2022 Aug 12;11(16):4713. doi: 10.3390/jcm11164713.
8
A Comprehensive Outlook on Dilated Cardiomyopathy (DCM): State-Of-The-Art Developments with Special Emphasis on OMICS-Based Approaches.扩张型心肌病(DCM)综述:最新进展,特别强调基于组学的方法
J Cardiovasc Dev Dis. 2022 Jun 1;9(6):174. doi: 10.3390/jcdd9060174.
9
Pentoxifylline in the Treatment of Cutaneous Leishmaniasis: A Randomized Clinical Trial in Colombia.己酮可可碱治疗皮肤利什曼病:哥伦比亚的一项随机临床试验
Pathogens. 2022 Mar 21;11(3):378. doi: 10.3390/pathogens11030378.
10
Noninvasive Systemic Modalities for Prevention of Head and Neck Radiation-Associated Soft Tissue Injury: A Narrative Review.用于预防头颈部放疗相关软组织损伤的非侵入性全身治疗方法:一项叙述性综述。
J Reconstr Microsurg. 2022 Oct;38(8):621-629. doi: 10.1055/s-0042-1742731. Epub 2022 Feb 25.
Asian Pac J Cancer Prev. 2011;12(4):971-4.
4
A systematic review of treatment of drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in children.儿童药物性史蒂文斯-约翰逊综合征和中毒性表皮坏死松解症治疗的系统评价
J Popul Ther Clin Pharmacol. 2011;18:e121-33. Epub 2011 Mar 21.
5
Pentoxifylline treatment and penile calcifications in men with Peyronie's disease.己酮可可碱治疗对伴阴茎硬结症男性的阴茎钙化的影响。
Asian J Androl. 2011 Mar;13(2):322-5. doi: 10.1038/aja.2010.117. Epub 2010 Nov 22.
6
Pentoxifylline in reactions in leprosy.
Indian J Dermatol Venereol Leprol. 1996 May-Jun;62(3):163-4.
7
An open trial of pentoxifylline in schamberg's disease.
Indian J Dermatol Venereol Leprol. 2000 Mar-Apr;66(2):73-5.
8
Pentoxifylline attenuates transforming growth factor-β1-stimulated collagen deposition and elastogenesis in human tunica albuginea-derived fibroblasts part 1: impact on extracellular matrix.己酮可可碱可减轻转化生长因子-β1刺激的人白膜来源成纤维细胞胶原沉积和弹性蛋白生成 第 1 部分:对细胞外基质的影响。
J Sex Med. 2010 Jun;7(6):2077-2085. doi: 10.1111/j.1743-6109.2010.01790.x. Epub 2010 Mar 30.
9
Oral pentoxifylline and topical clobetasol propionate ointment in the treatment of pretibial myxoedema, with concomitant improvement of Graves' ophthalmopathy.口服己酮可可碱和外用丙酸氯倍他索软膏治疗胫前黏液性水肿,并同时改善格雷夫斯眼病。
J Eur Acad Dermatol Venereol. 2007 Nov;21(10):1441-3. doi: 10.1111/j.1468-3083.2007.02259.x.
10
Treatment of Schamberg's disease with pentoxifylline--therapeutic trial.
Indian J Dermatol Venereol Leprol. 2003 Jan-Feb;69(1):25-6.