己酮可可碱及其在皮肤科的应用。
Pentoxifylline and its applications in dermatology.
作者信息
Hassan Iffat, Dorjay Konchok, Anwar Parvaiz
机构信息
Department of Dermatology, STD and Leprosy, Government Medical College Srinagar, University of Kashmir, Jammu and Kashmir, India.
出版信息
Indian Dermatol Online J. 2014 Oct;5(4):510-6. doi: 10.4103/2229-5178.142528.
Abstract
Pentoxifylline is a methyl-xanthine derivative with many anti inflammatory effects. Pentoxifylline has been found to be effective for many dermatological as well as non-dermatological conditions. It has been used both as primary drug as well as adjuvant and is a safe and relatively cost-effective alternative drug. In this article, we review the literature and highlight various important aspects of pentoxifylline.
摘要
己酮可可碱是一种具有多种抗炎作用的甲基黄嘌呤衍生物。已发现己酮可可碱对许多皮肤病学和非皮肤病学病症均有效。它既用作主要药物，也用作辅助药物，是一种安全且相对具有成本效益的替代药物。在本文中，我们回顾了相关文献并强调了己酮可可碱的各个重要方面。
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Pentoxifylline and its applications in dermatology.
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本文引用的文献
1
Venous ulcers of the lower limb: Where do we stand?
Indian J Plast Surg. 2012 May;45(2):266-74. doi: 10.4103/0970-0358.101294.
2
Lipodermatosclerosis: improvement noted with hydroxychloroquine and pentoxifylline.
J Am Acad Dermatol. 2012 Jun;66(6):1013-4. doi: 10.1016/j.jaad.2011.11.942.
3
Pentoxifylline therapy in the management of oral submucous fibrosis.
Asian Pac J Cancer Prev. 2011;12(4):971-4.
4
A systematic review of treatment of drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in children.
J Popul Ther Clin Pharmacol. 2011;18:e121-33. Epub 2011 Mar 21.
5
Pentoxifylline treatment and penile calcifications in men with Peyronie's disease.
Asian J Androl. 2011 Mar;13(2):322-5. doi: 10.1038/aja.2010.117. Epub 2010 Nov 22.
6
Pentoxifylline in reactions in leprosy.
Indian J Dermatol Venereol Leprol. 1996 May-Jun;62(3):163-4.
7
An open trial of pentoxifylline in schamberg's disease.
Indian J Dermatol Venereol Leprol. 2000 Mar-Apr;66(2):73-5.
8
Pentoxifylline attenuates transforming growth factor-β1-stimulated collagen deposition and elastogenesis in human tunica albuginea-derived fibroblasts part 1: impact on extracellular matrix.
J Sex Med. 2010 Jun;7(6):2077-2085. doi: 10.1111/j.1743-6109.2010.01790.x. Epub 2010 Mar 30.
9
Oral pentoxifylline and topical clobetasol propionate ointment in the treatment of pretibial myxoedema, with concomitant improvement of Graves' ophthalmopathy.
J Eur Acad Dermatol Venereol. 2007 Nov;21(10):1441-3. doi: 10.1111/j.1468-3083.2007.02259.x.
10
Treatment of Schamberg's disease with pentoxifylline--therapeutic trial.
Indian J Dermatol Venereol Leprol. 2003 Jan-Feb;69(1):25-6.
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