Department of Urology, University of California, San Francisco, CA, USA.
Asian J Androl. 2011 Mar;13(2):322-5. doi: 10.1038/aja.2010.117. Epub 2010 Nov 22.
This retrospective cohort study from a single clinical practice enrolled patients with evidence of calcified Peyronie's disease (PD) plaques detected on penile ultrasound at the time of initial presentation. The primary objective was to describe the effect of pentoxifylline (PTX) treatment on subtunical calcifications in men with PD. A PD-specific questionnaire was administered and sonographic evaluations were performed at baseline and follow-up visits. Descriptive statistics and χ(2) analysis were used to characterize the effect of PTX on calcified tunical plaques. In all, 71 men (mean age: 51.9 years) with PD and sonographic evidence of calcification were identified. Of them, 62 of these men were treated with PTX for a mean duration of 1 year, and nine with vitamin E or no treatment. Improvement or stabilization in calcium burden at follow-up was noted in 57 (91.9%) of men treated with PTX versus four (44.4%) of those not treated with PTX (P<0.001). PTX users were much less likely to have a subjective worsening of their clinical condition (25.0% versus 78.3%, P=0.002). Treatment with PTX appeared to stabilize or reduce calcium content in PD plaques. A randomized controlled trial is warranted to further explore this effect.
这项来自单一临床实践的回顾性队列研究纳入了在初始就诊时阴茎超声检查发现有钙化性 Peyronie 病（PD）斑块的患者。主要目的是描述在 PD 患者中，己酮可可碱（PTX）治疗对皮下钙化的影响。在基线和随访时进行了 PD 特定问卷和超声评估。采用描述性统计和 χ(2)分析来描述 PTX 对钙化性筋膜斑块的影响。共确定了 71 名（平均年龄：51.9 岁）有 PD 且超声有钙化证据的男性。其中，62 名接受了为期 1 年的 PTX 治疗，9 名接受了维生素 E 或未治疗。与未接受 PTX 治疗的 4 名（44.4%）相比，接受 PTX 治疗的患者在随访时钙负荷改善或稳定的有 57 名（91.9%）（P<0.001）。PTX 使用者出现临床状况主观恶化的可能性要小得多（25.0%比 78.3%，P=0.002）。PTX 治疗似乎稳定或减少了 PD 斑块中的钙含量。需要进行随机对照试验来进一步探讨这种效果。
