Wahlberg P, Fex G, Wennerberg J, Willén R
Department of Oto-Rhino-Laryngology, University Hospital of Lund, Sweden.
Anticancer Res. 1989 Jan-Feb;9(1):181-7.
A human ovarian mesodermal mixed heterologous carcinoma, with a high content of cellular retinol-binding protein (CRBP), was used to study the effects of retinoid and hormonal treatment on tumour CRBP content, tumour growth rate, differentiation and turnover of CRBP. Tumour growth in general was accompanied by an increase in the CRBP concentration of the xenografted tumours. This was related to the appearance of more mature epithelial cells, showing CRBP immunoreactivity. The increase in CRBP concentration was more pronounced in retinyl palmitate-treated tumours than in tumour tissue from etretinate- (an aromatic retinoid) treated mice and controls, suggesting that CRBP synthesis is under the influence of its ligand. Various hormonal treatments had no influence on the CRBP concentration in these tumour cells. The CRBP turnover was similar to that of the bulk of cellular proteins.
使用一种富含细胞视黄醇结合蛋白（CRBP）的人卵巢中胚层混合异源性癌，来研究类视黄醇和激素治疗对肿瘤CRBP含量、肿瘤生长速率、CRBP的分化和周转的影响。总体而言，肿瘤生长伴随着异种移植肿瘤中CRBP浓度的增加。这与出现更多显示CRBP免疫反应性的成熟上皮细胞有关。棕榈酸视黄酯处理的肿瘤中CRBP浓度的增加比依曲替酯（一种芳香族类视黄醇）处理的小鼠和对照的肿瘤组织中更明显，表明CRBP的合成受其配体的影响。各种激素治疗对这些肿瘤细胞中的CRBP浓度没有影响。CRBP的周转与大部分细胞蛋白的周转相似。
