[人皮肤肿瘤中游离视黄醇受体（细胞视黄醇结合蛋白，cRBP）和视黄酸受体（细胞视黄酸结合蛋白，cRABP）的存在情况]

[Presence of free retinol receptor (cRBP) and retinoic acid receptor (cRABP) in human skin tumors].

作者信息

Delarue J C, Avril M F, Prade M, Petit J Y

出版信息

Bull Cancer. 1986;73(2):193-200.

Abstract

The concentrations of cellular retinoic acid binding protein (cRABP) and free cellular retinol binding protein (cRBP) were determined by ultracentrifugation in sucrose gradient in the cytosol of 41 human skin tumours (14 melanomas, 19 basal cell carcinomas, 8 squamous cell carcinomas). cRBP was found respectively in 36%, 42% and 37% of the studied samples. On the contrary, cRABP was more frequently found in carcinomas (89% in basal cell carcinomas and 100% in squamous cell carcinomas) than in melanomas (21%) (p less than 0.001). These results are discussed according to the different embryologic origin of carcinomas and melanomas. Furthermore, the better efficiency of synthetic retinoids in carcinomas than in melanomas should be explained by a different way of action in these 2 kinds of tumours.

摘要

通过蔗糖梯度超速离心法测定了41例人类皮肤肿瘤（14例黑色素瘤、19例基底细胞癌、8例鳞状细胞癌）胞质溶胶中细胞视黄酸结合蛋白（cRABP）和游离细胞视黄醇结合蛋白（cRBP）的浓度。在所研究的样本中，分别有36%、42%和37%检测到cRBP。相反，cRABP在癌组织中（基底细胞癌中为89%，鳞状细胞癌中为100%）比在黑色素瘤中（21%）更常见（p<0.001）。根据癌和黑色素瘤不同的胚胎学起源对这些结果进行了讨论。此外，合成维甲酸在癌组织中的疗效优于黑色素瘤，这应通过这两种肿瘤不同的作用方式来解释。