Lu Zhaolian, Chen Yingjian, Hu Zhide, Hu Chengjin
Department of Laboratory Medicine, General Hospital of Ji'nan Military Command Region, Ji'nan, China.
Int J Gynecol Cancer. 2015 Jan;25(1):18-23. doi: 10.1097/IGC.0000000000000319.
This study aimed to assess the diagnostic value of lysophosphatidic acid (LPA) in ovarian cancer.
A systematic review of related studies was performed; sensitivity, specificity, and other measures about the accuracy of serum LPA in the diagnosis of ovarian cancer were pooled using random-effects models. Summary receiver operating characteristic curve analysis was used to summarize the overall test performance.
Six studies involving 363 patients with ovarian cancer and 273 healthy control women met the inclusion criteria. The summary estimates for LPA in diagnosing ovarian cancer in the included studies were as follows: sensitivity, 0.94 [95% confidence interval (CI), 0.91-0.96]; specificity, 0.88 (95% CI, 0.83-0.91); and diagnostic odds ratio, 141.59 (95% CI, 52.1-384.63). The area under the curve and Q value for summary receiver operating characteristic curves were 0.97 and 0.92, respectively.
The LPA assay showed high accuracy and sensitivity for the diagnosis of ovarian cancer. The present study was limited by the small number of available studies and sample size; therefore, additional studies with a better design and larger samples are needed to further assess the diagnostic accuracy of LPA.
本研究旨在评估溶血磷脂酸（LPA）在卵巢癌诊断中的价值。
对相关研究进行系统评价；采用随机效应模型汇总血清LPA诊断卵巢癌准确性的敏感性、特异性及其他指标。采用汇总受试者工作特征曲线分析来总结总体检验性能。
六项涉及363例卵巢癌患者和273名健康对照女性的研究符合纳入标准。纳入研究中LPA诊断卵巢癌的汇总估计值如下：敏感性为0.94[95%置信区间（CI），0.91 - 0.96]；特异性为0.88（95%CI，0.83 - 0.91）；诊断比值比为141.59（95%CI，52.1 - 384.63）。汇总受试者工作特征曲线的曲线下面积和Q值分别为0.97和0.92。
LPA检测对卵巢癌诊断具有较高的准确性和敏感性。本研究受可用研究数量和样本量较少的限制；因此，需要设计更好、样本量更大的进一步研究来进一步评估LPA的诊断准确性。
