Graziani A, Quercia O, Girelli F, Martelli A, Mirici Cappa F, Stefanini G F
UO Medicina Interna, Ospedale degli Infermi, Faenza, Italy - AUSL Ravenna Phone: +39 054 660 12 14 E-mail:
Ambulatorio Alta Specializzazione in Allergologia, Ospedale degli Infermi, Faenza, Italia.
Eur Ann Allergy Clin Immunol. 2014 Nov;46(6):226-8.
Eosinophilic Granulomatosis with Polyangiitis (EGPA), formerly named Churg Strauss Syndrome, is a multisystem disorder characterized by chronic rhinosinusitis, asthma, and prominent peripheral blood eosinophilia; it is classified as a vasculitis of the small and medium sized arteries, although the vasculitis is often not clinically apparent in the initial phases of the disease. We present the case of a woman with EGPA who was frequently treated with high dose steroid therapy during hospital admission for refractory asthma. After December 2008, the date when we started Omalizumab, we observed a significative reduction of circulating eosinophils and IgE serum level, and the patient was no more hospitalized for respiratory failure or asthma attacks.
嗜酸性肉芽肿性多血管炎（EGPA），以前称为变应性肉芽肿性血管炎，是一种多系统疾病，其特征为慢性鼻窦炎、哮喘和外周血嗜酸性粒细胞显著增多；它被归类为中小动脉血管炎，尽管在疾病的初始阶段血管炎通常在临床上并不明显。我们报告一例患有EGPA的女性病例，该患者在因难治性哮喘住院期间经常接受高剂量类固醇治疗。在2008年12月我们开始使用奥马珠单抗之后，我们观察到循环嗜酸性粒细胞和血清IgE水平显著降低，并且该患者不再因呼吸衰竭或哮喘发作而住院。
