非洲两个地理位置不同的队列中1型艾滋病毒中和广度的差异。
Differences in HIV type 1 neutralization breadth in 2 geographically distinct cohorts in Africa.
作者信息
Bandawe Gama P, Moore Penny L, Werner Lise, Gray Elin S, Sheward Daniel J, Madiga Maphuti, Nofemela Andile, Thebus Ruwayhida, Marais Jinny C, Maboko Leonard, Abdool Karim Salim S, Hoelscher Michael, Morris Lynn, Williamson Carolyn
机构信息
Institute of Infectious Diseases and Molecular Medicine Division of Medical Virology, University of Cape Town.
Centre for HIV and STIs, National Institute for Communicable Diseases, National Health Laboratory Services School of Pathology, University of the Witwatersrand, Johannesburg Centre for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Durban, South Africa.
出版信息
J Infect Dis. 2015 May 1;211(9):1461-6. doi: 10.1093/infdis/jiu633. Epub 2014 Nov 14.
To investigate whether distinct populations have differing human immunodeficiency virus type 1 (HIV) neutralizing antibody responses, we compared 20 women from Tanzania's HIV Superinfection Study (HISIS) cohort, who were infected multiple HIV subtypes, and 22 women from the Centre for the AIDS Programme of Research in South Africa (CAPRISA) cohort, who were infected exclusively with HIV subtype C. By 2 years after infection, 35% of HISIS subjects developed neutralization breadth, compared with 9% of CAPRISA subjects (P = .0131). Cumulative viral loads between 3 and 12 months were higher in the HISIS group (P = .046) and strongly associated with breadth (P < .0001). While viral load was the strongest predictor, other factors may play a role, as the odds of developing breadth remained higher in HISIS even after correction for viral load.
为了研究不同人群是否具有不同的1型人类免疫缺陷病毒（HIV）中和抗体反应，我们比较了来自坦桑尼亚HIV双重感染研究（HISIS）队列的20名女性和来自南非艾滋病研究项目中心（CAPRISA）队列的22名女性。HISIS队列中的女性感染了多种HIV亚型，而CAPRISA队列中的女性仅感染了HIV C亚型。感染后2年，35%的HISIS受试者产生了中和广度，而CAPRISA受试者中这一比例为9%（P = 0.0131）。HISIS组在3至12个月期间的累积病毒载量更高（P = 0.046），且与中和广度密切相关（P < 0.0001）。虽然病毒载量是最强的预测因素，但其他因素可能也起作用，因为即使在校正病毒载量后，HISIS组产生中和广度的几率仍然更高。
Zotero 插件