Caetano Tânia, Süssmuth Roderich D, Mendo Sónia
Department of Biology and CESAM, University of Aveiro, 3810, Aveiro, Portugal,
Curr Microbiol. 2015 Mar;70(3):364-8. doi: 10.1007/s00284-014-0727-0. Epub 2014 Nov 16.
Investigation on lantibiotics biosynthesis constitutes an emergent field, since these molecules have demonstrated a great potential to replace the so-called "traditional antibiotics". The adaptation of bacteria to laboratory conditions (domestication) is an unpredictable phenomenon, which sometimes is associated with the loss of important biotechnological properties. In this study, the domestication of Bacillus licheniformis was associated with the production of the lantibiotic lichenicidin, a two-peptide lantibiotic with activity against several Gram-positive bacteria.
对羊毛硫抗生素生物合成的研究构成了一个新兴领域，因为这些分子已显示出取代所谓“传统抗生素”的巨大潜力。细菌对实验室条件的适应（驯化）是一种不可预测的现象，有时与重要生物技术特性的丧失有关。在本研究中，地衣芽孢杆菌的驯化与羊毛硫抗生素地衣素的产生有关，地衣素是一种双肽羊毛硫抗生素，对几种革兰氏阳性菌具有活性。
