系统性硬化症患者甲襞毛细血管镜检查结果与肺功能测试之间的关联
Association between nailfold capillaroscopy findings and pulmonary function tests in patients with systemic sclerosis.
作者信息
Castellví Ivan, Simeón-Aznar Carmen Pilar, Sarmiento Mónica, Fortuna Ana, Mayos Mercedes, Geli Carme, Diaz-Torné César, Moya Patricia, De Llobet Josep Maria, Casademont Jordi
机构信息
From the Unit of Rheumatology, Department of Internal Medicine, Hospital de la Santa Creu i Sant Pau; Department of Internal Medicine, Hospital Universitari Valle Hebrón; Department of Pneumology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.I. Castellví, MD, Associate Professor of Medicine, Universitat Autònoma de Barcelona, Unit of Rheumatology, Hospital de la Santa Creu i Sant Pau; C.P. Simeón-Aznar, PhD, Department of Internal Medicine, Hospital Universitari Valle Hebrón; M. Sarmiento, MD; C. Geli, MD; C. Diaz-Torné, PhD, Associate Professor of Medicine; P. Moya, MD;J.M. De Llobet, MD, Unit of Rheumatology, Hospital de la Santa Creu i Sant Pau; A. Fortuna, MD; M. Mayos, MD, Department of Pneumology, Hospital de la Santa Creu i Sant Pau; J. Casademont, PhD, Professor of Medicine, Universitat Autònoma de Barcelona Department of Internal Medicine, Hospital de la Santa Creu i Sant Pau.
出版信息
J Rheumatol. 2015 Feb;42(2):222-7. doi: 10.3899/jrheum.140276. Epub 2014 Nov 15.
OBJECTIVE
To determine whether there is an association between different capillaroscopic findings and pulmonary function tests in systemic sclerosis (SSc).
METHODS
We did a retrospective observational study in a cohort of patients with SSc and early SSc. Patients with at least 1 nailfold videocapillaroscopy (NVC) magnified 120× were included. Pathological findings were giant capillaries, angiogenesis, and density loss. Findings were compared with lung function values: percent expected value of forced vital capacity (FVC), DLCO, and FVC/DLCO ratio. Other variables collected were sex and SSc type, and the presence of digital ulcers (DU), interstitial lung disease (ILD), scleroderma renal crisis, and/or pulmonary hypertension (PH).
RESULTS
Of 136 patients with SSc, 85 had undergone an NVC. The frequency of ILD, DU, and PH was 24.1%, 28.7%, and 17.2%, respectively. Data analysis showed that patients with density loss had worse FVC% (86.91 ± 19.42 vs 101.13 ± 16.06, p < 0.01) and DLCO% (71.43 ± 21.19 vs 85.9 ± 19.81, p < 0.01) compared to those without.
CONCLUSION
Patients with loss of density present worse FVC and DLCO values. Prospective studies are warranted to determine whether NVC is useful for studying pulmonary function in SSc.
目的
确定系统性硬化症（SSc）患者不同的毛细血管镜检查结果与肺功能测试之间是否存在关联。
方法
我们对一组SSc患者和早期SSc患者进行了一项回顾性观察研究。纳入至少有1次放大120倍的甲襞视频毛细血管镜检查（NVC）的患者。病理结果为巨大毛细血管、血管生成和密度降低。将这些结果与肺功能值进行比较：用力肺活量（FVC）的预期值百分比、一氧化碳弥散量（DLCO）以及FVC/DLCO比值。收集的其他变量包括性别、SSc类型，以及是否存在指端溃疡（DU）、间质性肺疾病（ILD）、硬皮病肾危象和/或肺动脉高压（PH）。
结果
在136例SSc患者中，85例接受了NVC检查。ILD、DU和PH的发生率分别为24.1%、28.7%和17.2%。数据分析显示，与无密度降低的患者相比，密度降低的患者FVC%更差（86.91±19.42对101.13±16.06，p<0.01），DLCO%也更差（71.43±21.19对85.9±19.81，p<0.01）。
结论
密度降低的患者FVC和DLCO值更差。有必要进行前瞻性研究以确定NVC是否有助于研究SSc患者的肺功能。
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