Moschetti Liala, Piantoni Silvia, Vizzardi Enrico, Sciatti Edoardo, Riccardi Mauro, Franceschini Franco, Cavazzana Ilaria
Rheumatology and Clinical immunology Unit, ASST Spedali Civili of Brescia, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Cardiology Unit, ASST Spedali Civili of Brescia, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy.
Front Med (Lausanne). 2022 Apr 8;9:849086. doi: 10.3389/fmed.2022.849086. eCollection 2022.
This review describes the complex interplay between inflammation, vasculopathy and fibrosis that involve the heart and peripheral small vessels, leading to endothelial stiffness, vascular damage, and early aging in patients with systemic lupus erythematosus and systemic sclerosis, which represents two different models of vascular dysfunction among systemic autoimmune diseases. In fact, despite the fact that diagnostic methods and therapies have been significantly improved in the last years, affected patients show an excess of cardiovascular mortality if compared with the general population. In addition, we provide a complete overview on the new techniques which are used for the evaluation of endothelial dysfunction in a preclinical phase, which could represent a new approach in the assessment of cardiovascular risk in these patients.
本综述描述了炎症、血管病变和纤维化之间复杂的相互作用，这些过程涉及心脏和外周小血管，导致系统性红斑狼疮和系统性硬化症患者出现内皮僵硬、血管损伤和早衰，这两种疾病代表了系统性自身免疫疾病中血管功能障碍的两种不同模式。事实上，尽管近年来诊断方法和治疗手段有了显著改善，但与普通人群相比，受影响患者的心血管死亡率仍然过高。此外，我们还全面概述了用于临床前阶段评估内皮功能障碍的新技术，这可能为评估这些患者的心血管风险提供一种新方法。
