Ma Lina, Li Ang, Zou Dong, Xu Xingjian, Xia Lin, Yu Jun, Bajic Vladimir B, Zhang Zhang
CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China.
CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China University of Chinese Academy of Sciences, Beijing 100049, China.
Nucleic Acids Res. 2015 Jan;43(Database issue):D187-92. doi: 10.1093/nar/gku1167. Epub 2014 Nov 15.
Long non-coding RNAs (lncRNAs) perform a diversity of functions in numerous important biological processes and are implicated in many human diseases. In this report we present lncRNAWiki (http://lncrna.big.ac.cn), a wiki-based platform that is open-content and publicly editable and aimed at community-based curation and collection of information on human lncRNAs. Current related databases are dependent primarily on curation by experts, making it laborious to annotate the exponentially accumulated information on lncRNAs, which inevitably requires collective efforts in community-based curation of lncRNAs. Unlike existing databases, lncRNAWiki features comprehensive integration of information on human lncRNAs obtained from multiple different resources and allows not only existing lncRNAs to be edited, updated and curated by different users but also the addition of newly identified lncRNAs by any user. It harnesses community collective knowledge in collecting, editing and annotating human lncRNAs and rewards community-curated efforts by providing explicit authorship based on quantified contributions. LncRNAWiki relies on the underling knowledge of scientific community for collective and collaborative curation of human lncRNAs and thus has the potential to serve as an up-to-date and comprehensive knowledgebase for human lncRNAs.
长链非编码RNA（lncRNAs）在众多重要生物学过程中发挥着多种功能，并与许多人类疾病相关。在本报告中，我们介绍了lncRNAWiki（http://lncrna.big.ac.cn），这是一个基于维基的平台，内容开放且可公开编辑，旨在通过社区协作来管理和收集人类lncRNAs的信息。当前相关数据库主要依赖专家管理，这使得对lncRNAs指数级积累的信息进行注释变得费力，而这不可避免地需要社区在lncRNAs管理方面的集体努力。与现有数据库不同，lncRNAWiki的特点是全面整合了从多种不同资源获得的人类lncRNAs信息，不仅允许不同用户对现有的lncRNAs进行编辑、更新和管理，还允许任何用户添加新发现的lncRNAs。它利用社区集体知识来收集、编辑和注释人类lncRNAs，并通过根据量化贡献提供明确的作者身份来奖励社区管理工作。lncRNAWiki依靠科学界的基础知识进行人类lncRNAs的集体协作管理，因此有潜力成为人类lncRNAs的最新综合知识库。
