Dayal Aggarwal Dau, Mishra Prachi, Yadav Gaurav, Mitra Shrishti, Patel Yashvant, Singh Manvender, Sahu Ranjan Kumar, Sharma Vijendra
Department of Biochemistry, University of Delhi South Campus, New Delhi, India.
Department of Zoology, Banaras Hindu University, Varanasi, India.
Heliyon. 2024 Jul 28;10(15):e35327. doi: 10.1016/j.heliyon.2024.e35327. eCollection 2024 Aug 15.
Obesity is a burgeoning global health problem with an escalating prevalence and severe implications for public health. New evidence indicates that long non-coding RNAs (lncRNAs) may play a pivotal role in regulating adipose tissue function and energy homeostasis across various species. However, the molecular mechanisms underlying obesity remain elusive.
This review discusses obesity and fat metabolism in general, highlighting the emerging importance of lncRNAs in modulating adipogenesis. It describes the regulatory networks, latest tools, techniques, and approaches to enhance our understanding of obesity and its lncRNA-mediated epigenetic regulation in humans and .
This review analyses large datasets of human and lncRNAs from published databases and literature with experimental evidence supporting lncRNAs role in fat metabolism. It concludes that lncRNAs play a crucial role in obesity-related metabolism. Cross-species comparisons highlight the relevance of findings to human obesity, emphasizing their potential role in adipose tissue biology. Furthermore, it discusses how recent technological advancements and multi-omics data integration enhance our capacity to characterize lncRNAs and their function. Additionally, this review briefly touches upon innovative methodologies like experimental evolution and advanced sequencing technologies for identifying novel genes and lncRNA regulators in , which can potentially contribute to obesity research.
肥胖是一个迅速发展的全球健康问题，其患病率不断上升，对公众健康有着严重影响。新证据表明，长链非编码RNA（lncRNA）可能在调节不同物种的脂肪组织功能和能量平衡中发挥关键作用。然而，肥胖背后的分子机制仍不清楚。
本综述总体讨论肥胖和脂肪代谢，强调lncRNA在调节脂肪生成中日益重要的作用。它描述了调节网络、最新工具、技术和方法，以增进我们对人类肥胖及其lncRNA介导的表观遗传调控的理解。
本综述分析了已发表数据库和文献中关于人类和lncRNA的大型数据集，并有实验证据支持lncRNA在脂肪代谢中的作用。结论是lncRNA在肥胖相关代谢中起关键作用。跨物种比较突出了这些发现与人类肥胖的相关性，强调了它们在脂肪组织生物学中的潜在作用。此外，还讨论了最近的技术进步和多组学数据整合如何增强我们表征lncRNA及其功能的能力。此外，本综述简要提及了实验进化和先进测序技术等创新方法，用于鉴定lncRNA中的新基因和调节因子，这可能有助于肥胖研究。
