Björkman Louise, Ohlin Andreas
Department of Pediatrics, Faculty of Medicine and Health, Örebro University, SE 701 82, Örebro, Sweden.
Acta Paediatr. 2015 Mar;104(3):232-6. doi: 10.1111/apa.12866. Epub 2015 Jan 30.
The aim of this study was to investigate whether scrubbing the hub of intravenous catheters with an alcohol wipe for 15 sec could reduce the incidence of neonatal sepsis in a level-three neonatal intensive care unit.
We studied the incidence of neonatal sepsis caused by coagulase-negative staphylococci (CoNS) for 16.5 months before the initiative was launched on May 15, 2012 and then for a further 8.5 months after it was introduced. The hub routine was applied to all intravenous catheters.
During the control period before the initiative was launched, there were nine cases of CoNS sepsis compared with no cases after it was introduced, resulting in a decrease in sepsis incidence from 1.5% to 0% with a risk reduction of 1.5% (0.53-2.58%) (p = 0.06). In the preterm infant population, the incidence of sepsis decreased from 3.6% to 0% (1.1-6.0%) (p = 0.11).
Scrubbing the hub of intravenous catheters with an alcohol wipe for 15 sec seemed to be an efficient way of preventing sepsis caused by CoNS in newborn infants. However, the evidence for the benefits will remain weak until a large randomised trial has been completed.
本研究旨在调查在三级新生儿重症监护病房中，用酒精擦拭静脉导管接头15秒是否能降低新生儿败血症的发生率。
我们研究了在2012年5月15日该举措实施前16.5个月以及实施后另外8.5个月期间，由凝固酶阴性葡萄球菌（CoNS）引起的新生儿败血症的发生率。该接头常规操作应用于所有静脉导管。
在该举措实施前的对照期内，有9例CoNS败血症病例，而实施后无病例，败血症发生率从1.5%降至0%，风险降低了1.5%（0.53 - 2.58%）（p = 0.06）。在早产儿群体中，败血症发生率从3.6%降至0%（1.1 - 6.0%）（p = 0.11）。
用酒精擦拭静脉导管接头15秒似乎是预防新生儿由CoNS引起的败血症的有效方法。然而，在完成一项大型随机试验之前，支持其益处的证据仍将不足。
