传统蛋白激酶C和新型蛋白激酶C的差异靶向作用可解码并调节钙离子和脂质信号传导。

Differential targeting of cPKC and nPKC decodes and regulates Ca²⁺ and lipid signalling.

作者信息

Hui Xin, Kaestner Lars, Lipp Peter

机构信息

*Molecular Cell Biology, Research Centre for Molecular Imaging and Screening, Medical Faculty, Saarland University, Kirrberger Strasse 100, Homburg, Saarland 66424, Germany.

出版信息

Biochem Soc Trans. 2014 Dec;42(6):1538-42. doi: 10.1042/BST20140239.

DOI:10.1042/BST20140239

PMID:25399567

Abstract

Protein kinases C (PKCs) are ubiquitously expressed and play critical roles in a plethora of physiological and pathophysiological processes. Owing to PKCs' highly conserved phosphorylation consensus sequence, it has been difficult to distinguish the role of individual PKC isoforms. Recently, the identification of novel membrane targeting via subcellularly targeted diacylglycerol production found for novel PKCs (nPKCs), together with a characterization of their putative functions, has shed new light on the specific roles of individual PKCs in cellular processes.

摘要

蛋白激酶C（PKCs）广泛表达，在众多生理和病理生理过程中发挥关键作用。由于PKCs具有高度保守的磷酸化共有序列，因此很难区分各个PKC亚型的作用。最近，通过亚细胞靶向二酰基甘油生成对新型PKCs（nPKCs）进行新型膜靶向的鉴定，以及对其假定功能的表征，为各个PKCs在细胞过程中的特定作用提供了新的线索。