Saif Jaimy, Emanueli Costanza
*Bristol Heart Institute, School of Clinical Sciences, Bristol Royal Infirmary-Level 7, University of Bristol, Bristol BS2 8HW, U.K.
Biochem Soc Trans. 2014 Dec;42(6):1629-36. doi: 10.1042/BST20140263.
miRNAs are highly conserved non-coding RNA molecules that negatively control gene expression by binding to target mRNAs promoting their degradation. A multitude of miRNAs have been reported to be involved in angiogenesis and vascular remodelling. In the present review, we aim to describe the effect of miRNAs in post-ischaemic repair. First, we describe the miRNAs reported in ischaemic diseases and in angiogenesis. Then we examine their capacity to modulate the behaviour of stem and progenitor cells which could be utilized for vascular repair. And finally we discuss the potential of miRNAs as new clinical biomarkers and therapeutic targets.
微小RNA（miRNA）是高度保守的非编码RNA分子，通过与靶信使核糖核酸（mRNA）结合促进其降解来负向调控基因表达。据报道，众多miRNA参与血管生成和血管重塑。在本综述中，我们旨在描述miRNA在缺血后修复中的作用。首先，我们描述在缺血性疾病和血管生成中报道的miRNA。然后，我们研究它们调节可用于血管修复的干细胞和祖细胞行为的能力。最后，我们讨论miRNA作为新的临床生物标志物和治疗靶点的潜力。
