First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
Tianjin Key Laboratory of Traditional Research of TCM Prescription and Syndrome, Tianjin 300193, China.
Biomed Res Int. 2019 Feb 3;2019:9450240. doi: 10.1155/2019/9450240. eCollection 2019.
An increasing number of research studies over recent years have focused on the function of microRNA (miRNA) molecules which have unique characteristics in terms of structure and function. They represent a class of endogenous noncoding single-strand small molecules. An abundance of miRNA clusters has been found in the genomes of various organisms often located in a polycistron. The miR-17-92 family is among the most famous miRNAs and has been identified as an oncogene. The functions of this cluster, together with the seven individual molecules that it comprises, are most related to cancers, so it would not be surprising that they are considered to have involvement in the development of tumors. The miR-17-92 cluster is therefore expected not only to be a tumor marker, but also to perform an important role in the early diagnosis of those diseases and possibly also be a target for tumor biotherapy. The miR-17-92 cluster affects the development of disease by regulating many related cellular processes and multiple target genes. Interestingly, it also has important roles that cannot be ignored in disease of the nervous system and circulation and modulates the growth and development of bone. Therefore, it provides new opportunities for disease prevention, clinical diagnosis, prognosis, and targeted therapy. Here we review the role of the miR-17-92 cluster that has received little attention in relation to neurological diseases, cardiac diseases, and the development of bone and tumors.
近年来，越来越多的研究集中在 microRNA（miRNA）分子的功能上，这些分子在结构和功能上具有独特的特征。它们代表了一类内源性非编码单链小分子。大量的 miRNA 簇已在各种生物体的基因组中被发现，通常位于多顺反子中。miR-17-92 家族是最著名的 miRNAs 之一，被鉴定为癌基因。这个簇的功能以及它所包含的七个单个分子与癌症最相关，因此它们被认为参与肿瘤的发展也就不足为奇了。因此，miR-17-92 簇不仅有望成为肿瘤标志物，而且在这些疾病的早期诊断中也将发挥重要作用，并且可能成为肿瘤生物治疗的靶点。miR-17-92 簇通过调节许多相关的细胞过程和多个靶基因来影响疾病的发展。有趣的是，它在神经系统和循环系统疾病以及骨骼生长发育中也具有不可忽视的重要作用。因此，它为疾病预防、临床诊断、预后和靶向治疗提供了新的机会。在这里，我们回顾了 miR-17-92 簇的作用，该作用在神经系统疾病、心脏病以及骨骼和肿瘤的发育方面尚未得到充分关注。
