Favara David M, Banham Alison H, Harris Adrian L
‡NDCLS-Radcliffe Department of Medicine, University of Oxford, Oxford, U.K.
*Department of Oncology, University of Oxford, Oxford, U.K.
Biochem Soc Trans. 2014 Dec;42(6):1658-64. doi: 10.1042/BST20140216.
Epidermal growth factor, latrophilin and seven-transmembrane domain-containing 1 (ELTD1), an orphan G-protein-coupled receptor (GPCR) belonging to the adhesion GPCR family, has recently been identified as a potential cancer biomarker and a novel regulator of angiogenesis. In this mini-review, we present an overview of the current literature on ELTD1 and present bioinformatics data showing ELTD1's sequence conservation, its expression in cancer cell lines and its mutational frequency in human cancers. Additionally, we present sequence homology alignment results confirming ELTD1 to be a hybrid comprising motifs shared with individual members in both adhesion GPCR subfamilies 1 and 2. Finally, we discuss why tumour endothelial ELTD1 expression may confer a good prognosis yet still represent a therapeutic target.
表皮生长因子、促食欲素受体与含七次跨膜结构域蛋白1（ELTD1）是一种属于粘附G蛋白偶联受体（GPCR）家族的孤儿G蛋白偶联受体，最近被确定为一种潜在的癌症生物标志物和血管生成的新型调节因子。在本综述中，我们概述了目前关于ELTD1的文献，并展示了生物信息学数据，这些数据显示了ELTD1的序列保守性、其在癌细胞系中的表达以及在人类癌症中的突变频率。此外，我们展示了序列同源性比对结果，证实ELTD1是一种杂种，包含与粘附GPCR亚家族1和2中的个别成员共有的基序。最后，我们讨论了为什么肿瘤内皮ELTD1表达可能预示着良好的预后，但仍可作为一个治疗靶点。
