Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Medicine and Pharmacy, 200349 Craiova, Romania.
Department of Biochemistry, Faculty of Medicine, University of Medicine and Pharmacy, 200349 Craiova, Romania.
Int J Mol Sci. 2021 May 13;22(10):5151. doi: 10.3390/ijms22105151.
The epidermal growth factor, latrophilin, and seven transmembrane domain-containing protein 1 (ELTD1), is a member of the G-protein coupled receptors (GPCRs) superfamily. Although discovered in 2001, ELTD1 has been investigated only by a few research groups, and important data about its role in normal and tumor cells is still missing. Even though its functions and structure are not yet fully understood, recent studies show that ELTD1 has a role in both physiological and pathological angiogenesis, and it appears to be a very important biomarker and a molecular target in cancer diseases. Upregulation of ELTD1 in malignant cells has been reported, and correlated with poor cancer prognosis. This review article aims to compile the existing data and to discuss the current knowledge on ELTD1 structure and signaling, and its role in physiological and neoplastic conditions.
表皮生长因子、拉托啡林和七跨膜结构域蛋白 1（ELTD1）是 G 蛋白偶联受体（GPCR）超家族的成员。尽管它在 2001 年被发现，但只有少数研究小组对其进行了研究，关于它在正常和肿瘤细胞中的作用的重要数据仍然缺失。尽管其功能和结构尚未完全了解，但最近的研究表明，ELTD1 在生理和病理性血管生成中都有作用，并且似乎是癌症疾病中非常重要的生物标志物和分子靶标。已有报道称恶性细胞中 ELTD1 的上调与癌症预后不良相关。本文旨在汇总现有数据，讨论 ELTD1 结构和信号转导及其在生理和肿瘤状态下的作用的现有知识。
