细胞外细胞应激蛋白作为人类疾病的生物标志物。

Extracellular cell stress proteins as biomarkers of human disease.

作者信息

Pockley A Graham, Henderson Brian, Multhoff Gabriele

机构信息

*The John van Geest Cancer Research Centre, Nottingham Trent University, Nottingham NG11 8NS, U.K.

†Department of Microbial Diseases, UCL-Eastman Dental Institute, University College London, London WC1X 8LD, U.K.

出版信息

Biochem Soc Trans. 2014 Dec;42(6):1744-51. doi: 10.1042/BST20140205.

DOI:10.1042/BST20140205

PMID:25399600

Abstract

Although heat-shock (cell stress) proteins are commonly considered as being intracellular molecular chaperones that undertake a number of cytoprotective and cellular housekeeping functions, there is now a wealth of evidence to indicate that these proteins can be released by cells via active processes. Many molecular chaperones are secreted, or exist as cell surface proteins which can act as powerful signalling agonists and also as receptors for selected ligands. Levels of heat-shock (cell stress) proteins in biological fluids are now being associated with a plethora of clinical conditions, and these proteins therefore have potential utility as biomarkers of disease and/or response to therapeutic intervention. The present article summarizes current knowledge relating to extracellular cell stress proteins as biomarkers of human disease.

摘要

尽管热休克（细胞应激）蛋白通常被认为是承担多种细胞保护和细胞内务管理功能的细胞内分子伴侣，但现在有大量证据表明这些蛋白可通过主动过程被细胞释放。许多分子伴侣会被分泌出来，或以细胞表面蛋白的形式存在，它们既可以作为强大的信号激动剂，也可以作为特定配体的受体。生物体液中的热休克（细胞应激）蛋白水平现在与多种临床病症相关，因此这些蛋白作为疾病和/或治疗干预反应的生物标志物具有潜在用途。本文总结了与细胞外细胞应激蛋白作为人类疾病生物标志物相关的当前知识。