Renal Medicine, Royal Brisbane and Women's Hospital , Brisbane, Queensland , Australia .
Biomarkers. 2014 Mar;19(2):154-8. doi: 10.3109/1354750X.2013.867533. Epub 2014 Feb 13.
Oxidative stress biomarkers may have a role in the future to assist clinical decisions regarding the use of antioxidant therapies and their efficacy. The aims of this study were to evaluate the within and between-individual variability of plasma oxidative stress biomarkers and investigate factors affecting their variability. Plasma F2-isoprostanes and protein carbonyls were measured in 14 hemodialysis patients every 2 weeks for 10 weeks. Within-individual coefficients of variation (CVs) were isoprostanes = 30.4% (range = 6.1-66.7%) and protein carbonyls = 16.3% (8.4-29.5%). Between-individual CVs were isoprostanes = 34.4% (28.9-40.2%) and protein carbonyls = 19.5% (15.6-24.5%). There were no significant (p > 0.05) relationships between the oxidative stress biomarkers and dietary antioxidant intake, medications, clinical and demographic parameters.
氧化应激生物标志物可能在未来有助于临床决策，包括抗氧化治疗的应用及其疗效。本研究旨在评估血浆氧化应激生物标志物的个体内和个体间变异性，并探讨影响其变异性的因素。14 名血液透析患者每 2 周接受一次为期 10 周的血浆 F2-异前列腺素和蛋白质羰基的测量。个体内变异系数（CV）为异前列腺素=30.4%（范围为 6.1-66.7%）和蛋白质羰基=16.3%（8.4-29.5%）。个体间 CV 为异前列腺素=34.4%（28.9-40.2%）和蛋白质羰基=19.5%（15.6-24.5%）。氧化应激生物标志物与饮食抗氧化剂摄入、药物、临床和人口统计学参数之间无显著（p>0.05）关系。
