硬化性胆管炎中的胆管癌。肝移植的作用。
Cholangiocarcinoma in sclerosing cholangitis. The role of liver transplantation.
作者信息
Stieber A C, Marino I R, Iwatsuki S, Starzl T E
机构信息
Department of Surgery, University of Pittsburgh Health Center, Pennsylvania.
出版信息
Int Surg. 1989 Jan-Mar;74(1):1-3.
Abstract
Our experience with patients who underwent orthotopic liver transplantation for sclerosing cholangitis at the University of Pittsburgh Health Center between March 1980 and March 1988 is reported here. Ten patients had an associated cholangiocarcinoma. Six of these patients died of recurrent, disseminated cancer, usually before one year. One patient died of sepsis, while three are alive and apparently free of tumor four months to almost two years later. Pre-operative identification of a possible cholangiocarcinoma and complete resection are of crucial importance. Adjuvant therapy, especially pre-transplant radiation with a prophylactic purpose is still being evaluated.
摘要
本文报告了1980年3月至1988年3月间在匹兹堡大学健康中心接受原位肝移植治疗硬化性胆管炎患者的经验。10例患者伴有胆管癌。其中6例患者死于复发性播散性癌症，通常在1年内。1例患者死于败血症，3例患者存活，4个月至近2年后显然无肿瘤。术前识别可能的胆管癌并进行完全切除至关重要。辅助治疗，尤其是预防性的移植前放疗仍在评估中。
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