铁和钴催化氮杂环丁烷、吡咯烷和哌啶与格氏试剂的芳基化反应。

Iron- and cobalt-catalyzed arylation of azetidines, pyrrolidines, and piperidines with Grignard reagents.

作者信息

Barré Baptiste, Gonnard Laurine, Campagne Rémy, Reymond Sébastien, Marin Julien, Ciapetti Paola, Brellier Marie, Guérinot Amandine, Cossy Janine

机构信息

†Laboratoire de Chimie Organique, Institute of Chemistry, Biology and Innovation (CBI)-UMR 8231 ESPCI ParisTech, CNRS, PSL Research University, 10, Rue Vauquelin 75231 Paris Cedex 05, France.

‡NovAliX, BioParc, 850 Bld Sébastien Brant, BP 30170, F-67405 Illkirch, Cedex, France.

出版信息

Org Lett. 2014 Dec 5;16(23):6160-3. doi: 10.1021/ol503043r. Epub 2014 Nov 17.

DOI:10.1021/ol503043r

PMID:25401684

Abstract

Iron- and cobalt-catalyzed cross-couplings between iodo-azetidines, -pyrrolidines, -piperidines, and Grignard reagents are disclosed. The reaction is efficient, cheap, chemoselective and tolerates a large variety of (hetero)aryl Grignard reagents.

摘要

本文公开了铁和钴催化的碘代氮杂环丁烷、吡咯烷、哌啶与格氏试剂之间的交叉偶联反应。该反应高效、廉价、具有化学选择性，并且能耐受多种（杂）芳基格氏试剂。