钴催化的饱和环状胺与格氏试剂的（杂）芳基化反应。
Cobalt-Catalyzed (Hetero)arylation of Saturated Cyclic Amines with Grignard Reagents.
机构信息
Laboratoire de Chimie Organique, Institute of Chemistry, Biology and Innovation (CBI)-UMR 8231 ESPCI Paris, CNRS, PSL Research University 10, rue Vauquelin 75231 Paris CEDEX 05, France.
出版信息
Molecules. 2018 Jun 14;23(6):1449. doi: 10.3390/molecules23061449.
Abstract
(Hetero)aryl substituted saturated cyclic amines are ubiquitous scaffolds in biologically active molecules. Metal-catalyzed cross-couplings between halogeno -heterocycles and organometallic species are efficient and modular reactions to access these attractive scaffolds. An overview of our work concerning the cobalt-catalyzed arylation of iodo-substituted cyclic amines is presented.
摘要
杂芳基取代的饱和环状胺是生物活性分子中普遍存在的骨架。卤代杂环化合物与有机金属物种之间的金属催化交叉偶联是获得这些有吸引力的骨架的有效和模块化反应。本文介绍了我们关于钴催化碘代环状胺芳基化反应的工作概述。
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