Mason John O, Patel Shyam A
*Department of Ophthalmology, University of Alabama School of Medicine, Birmingham, Alabama; and †Retina Consultants of Alabama, Callahan Eye Foundation Hospital, Birmingham, Alabama.
Retin Cases Brief Rep. 2015 Spring;9(2):131-3. doi: 10.1097/ICB.0000000000000115.
To report a very rare case of bilateral Bull's eye maculopathy caused by sertraline.
Clinical case report and literature review.
A 14-year-old girl.
A 14-year-old girl with no significant medical history developed bilateral Bull's eye maculopathy after taking sertraline for 1 year. Diagnostic work-up, which consisted of electrooculography, electroretinography, and genetic testing, yielded no abnormal results. Three-year follow-up examination after discontinuation of sertraline showed no improvement in visual acuity (20/200 bilaterally) or retinal pigment epithelium. This is the second published case, and according to the National Registry of Drug-Induced Ocular Side Effects, this is only the fifth reported case of presumed sertraline maculopathy.
Although Bull's eye maculopathy related to sertraline is rare, physicians and patients need to be aware of the possible toxicity.
报告一例由舍曲林引起的双侧靶心样黄斑病变的罕见病例。
临床病例报告及文献复习。
一名14岁女孩。
一名无重大病史的14岁女孩在服用舍曲林1年后出现双侧靶心样黄斑病变。包括眼电图、视网膜电图和基因检测在内的诊断性检查未发现异常结果。停用舍曲林后的三年随访检查显示视力（双侧均为20/200）或视网膜色素上皮无改善。这是第二篇发表的病例，根据国家药物性眼部副作用登记处的数据，这是第五例报告的疑似舍曲林黄斑病变病例。
尽管与舍曲林相关的靶心样黄斑病变罕见，但医生和患者需要意识到可能的毒性。
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