Iwagaki H, Fuchimoto S, Orita K
First Department of Surgery, Okayama University Medical School, Japan.
J Med. 1989;20(1):83-95.
The histopathologic changes following chemotherapy treatment of fresh human tumors implanted under the renal capsule of normal immunocompetent mice were evaluated. On the basis of the histopathologic profile of the xenografts, four parameters were recognized: (1) cancer area (C), (2) necrosis area (N) (each measured by image analysis), (3) pathologic effect of cancer cells (P) (assessed histopathologically), and (4) number of mitoses (M) (counted microscopically), and were scored in a semiquantitative fashion from 0 to 2 or 4. The drug sensitivity (S) was scored using the following formula: S = C + P + M - N; this score varied from -4 to 10. Histopathologic changes represent a sensitive indicator of the response of implanted human tumors under the renal capsule to anticancer drugs. Availability and correct interpretation of the post-treatment histopathologic picture is of importance in selecting the proper combination treatment which would maximize tumor response.
评估了正常免疫活性小鼠肾被膜下植入新鲜人类肿瘤后化疗的组织病理学变化。根据异种移植物的组织病理学特征，确定了四个参数：（1）癌面积（C），（2）坏死面积（N）（均通过图像分析测量），（3）癌细胞的病理效应（P）（通过组织病理学评估），以及（4）有丝分裂数（M）（显微镜下计数），并以半定量方式从0到2或4进行评分。药物敏感性（S）使用以下公式评分：S = C + P + M - N；该评分范围为-4至10。组织病理学变化是肾被膜下植入的人类肿瘤对抗癌药物反应的敏感指标。治疗后组织病理学图像的可用性和正确解读对于选择能使肿瘤反应最大化的合适联合治疗至关重要。
