Marek J, Bechynĕ M
2nd Department of Pathological Anatomy, Medical Faculty, Charles University, Prague, Czechoslovakia.
Neoplasma. 1990;37(1):23-30.
The subrenal capsule assay (SRC) in immunocompetent mice became one of commonly used approaches to evaluating the efficiency of cytostatic therapy. A comparison of the classical macroscopic evaluation according to the Bogden diagram with results of the histopathologic examination in 118 mice with implanted Yoshida sarcoma or human rectal adenocarcinoma demonstrated the tumor to be present to different extent only in 26 out of 50 macroscopically positive cases and, on the other hand, it was found in 3 out of 68 macroscopically negative animals. Histological changes in these cases, as well as a study of the dynamics of the development of histopathologic changes after tumor implantation and the changes after implantation of inert materials demonstrated that the resorptive and reparative granuloma, originating in immunocompetent mice under the renal capsule after implanting the tumor or other materials, simulates perfectly the growth of the tumor infiltrate. For this reason we consider this method in immunocompetent mice as unreliable when there is no parallel histological examination.
在免疫活性小鼠中进行的肾包膜下试验（SRC）成为评估细胞抑制疗法疗效的常用方法之一。将根据博登图进行的经典宏观评估与118只植入吉田肉瘤或人直肠腺癌的小鼠的组织病理学检查结果进行比较，结果显示，在50例宏观检查呈阳性的病例中，只有26例在不同程度上存在肿瘤；另一方面，在68例宏观检查呈阴性的动物中，有3例发现了肿瘤。这些病例中的组织学变化，以及对肿瘤植入后组织病理学变化发展动态和惰性材料植入后变化的研究表明，在植入肿瘤或其他材料后，免疫活性小鼠肾包膜下产生的吸收性和修复性肉芽肿完美模拟了肿瘤浸润的生长。因此，我们认为，在没有并行组织学检查的情况下，这种在免疫活性小鼠中进行的方法是不可靠的。
