慢性心力衰竭患者血清髓过氧化物酶水平与心脏型脂肪酸结合蛋白相关，但与肌钙蛋白T无关。
Serum myeloperoxidase level is associated with heart-type fatty acid-binding protein but not troponin T in patients with chronic heart failure.
作者信息
Gedikli Omer, Kiris Abdulkadir, Hosoglu Yusuf, Karahan Caner, Kaplan Sahin
机构信息
Department of Cardiology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
出版信息
Med Princ Pract. 2015;24(1):42-6. doi: 10.1159/000368717. Epub 2014 Nov 15.
OBJECTIVE
Our aim was to investigate the possible relationship between myeloperoxidase (MPO) and myocardial damage markers such as heart-type fatty acid-binding protein (H-FABP) and troponin T (TnT) in patients with chronic heart failure (HF).
MATERIALS AND METHODS
Forty-two consecutive patients (age range: 27-80 years) with chronic HF were enrolled in the study. Serum H-FABP, TnT and MPO levels were measured. Routine biochemical and clinical parameters were recorded. Echocardiographic examinations were performed on all patients. A linear regression analysis was performed to determine the correlates of serum H-FABP.
RESULTS
The MPO, H-FABP and TnT levels were 255 ± 227, 60.6 ± 48.5 and 0.07 ± 0.15 ng/ml, respectively. In multiple linear regression analysis, age (β = -0.36, p = 0.006), creatinine level (β = 0.3, p = 0.024) and serum MPO level (β = 0.41, p = 0.009) were significant determinants of H-FABP levels. Bivariate predictors were not significantly associated with TnT levels in linear regression analyses.
CONCLUSIONS
The MPO was significantly associated with serum H-FABP levels but not with TnT.
目的
我们的目的是研究慢性心力衰竭（HF）患者中髓过氧化物酶（MPO）与心肌损伤标志物如心脏型脂肪酸结合蛋白（H-FABP）和肌钙蛋白T（TnT）之间的可能关系。
材料与方法
连续纳入42例慢性HF患者（年龄范围：27 - 80岁）进行研究。检测血清H-FABP、TnT和MPO水平。记录常规生化和临床参数。对所有患者进行超声心动图检查。进行线性回归分析以确定血清H-FABP的相关因素。
结果
MPO、H-FABP和TnT水平分别为255±227、6±48.5和0.07±0.15 ng/ml。在多元线性回归分析中，年龄（β = -0.36，p = 0.006）、肌酐水平（β = 0.3，p = 0.024）和血清MPO水平（β = 0.41，p = 0.009）是H-FABP水平的显著决定因素。在线性回归分析中，双变量预测因子与TnT水平无显著相关性。
结论
MPO与血清H-FABP水平显著相关，但与TnT无关。
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