Ikitimur Baris, Karadag Bilgehan
Department of Cardiology, Cerrahpasa School of Medicine, Istanbul University, 34098 Istanbul, Turkey.
Future Cardiol. 2010 Sep;6(5):693-702. doi: 10.2217/fca.10.75.
Myeloperoxidase (MPO) is an enzyme found in myeloid cells, particularly in neutrophils, and to a lesser extent in monocytes and tissue macrophages. MPO plays an important role in the host defense against bacteria and viruses. Since MPO is also an important enzyme in the inflammatory process, and inflammation is a key component in the development and progression of atherosclerotic and other forms of cardiovascular disease, there is ongoing interest in the use of MPO as a biomarker in different fields of cardiology. We aimed to review the current state of literature regarding the role of MPO in cardiovascular disease, especially highlighting the practical implications of the fast growing data from clinical studies.
髓过氧化物酶（MPO）是一种存在于髓样细胞中的酶，特别是在中性粒细胞中，在单核细胞和组织巨噬细胞中的含量较少。MPO在宿主抵御细菌和病毒的防御中发挥着重要作用。由于MPO也是炎症过程中的一种重要酶，而炎症是动脉粥样硬化和其他形式心血管疾病发生和发展的关键组成部分，因此人们一直对将MPO用作心脏病学不同领域的生物标志物感兴趣。我们旨在综述关于MPO在心血管疾病中作用的当前文献状态，特别强调临床研究中快速增长的数据的实际意义。
