Mashin V V, Belova L A, Chaplanova O I, Khusnullina A F, Manasian A M
Zh Nevrol Psikhiatr Im S S Korsakova. 2014;114(9):49-52.
to study cortexin efficacy in treatment of cognitive and affective disorders in brain ischemia (BI) comorbid to arterial hypertension and/or atherosclerosis.
The results of the all-Russian screening of cortexin efficacy "Cognitive and affective disorders during treatment brain ischemia with cortexin" conducted in 50 000 patients with BI in 70 Russian cities in 2013 were used for an analysis. All patients received cortexin in dose 10 mg/day during 10 days. Patients were examined before treatment and 11 and 30 days after the beginning of treatment. We analyzed treatment results for 500 patients with BI, stage II, mean age 63,7 ± 10,23 years. Treatment efficacy was assessed using 5-score scale of subjective and objective neurological symptoms, the Five words test, the Schulte test, MMSE, Hamilton anxiety scale and a brief version of the Geriatric depression scale.
A decrease or complete regression of focal neurological symptoms, positive changes in indicators of cognitive impairment, normalization of emotional status and decrease in depression level were noted during the treatment.
研究皮质素对治疗合并动脉高血压和/或动脉粥样硬化的脑缺血（BI）所致认知和情感障碍的疗效。
分析2013年在俄罗斯70个城市对50000例脑缺血患者进行的全俄皮质素疗效筛查“使用皮质素治疗脑缺血时的认知和情感障碍”的结果。所有患者均接受剂量为10毫克/天的皮质素治疗，持续10天。在治疗前以及治疗开始后11天和30天对患者进行检查。我们分析了500例II期脑缺血患者的治疗结果，这些患者的平均年龄为63.7±10.23岁。使用主观和客观神经症状的5分制量表、五个单词测试、舒尔特测试、简易精神状态检查表（MMSE）、汉密尔顿焦虑量表和老年抑郁量表简版对治疗效果进行评估。
治疗期间观察到局灶性神经症状减轻或完全消退、认知障碍指标出现积极变化、情绪状态恢复正常以及抑郁水平降低。
