Reda A, Abdel-Rehim A A, Etman A, Afifi O S A
College of Medicine, Menoufiya University, Shebin El-Kom, Egypt.
Diabetes and Metabolism Unit, Alexandria University, Alexandria, Egypt.
Cardiol Ther. 2014 Dec;3(1-2):27-40. doi: 10.1007/s40119-014-0031-x. Epub 2014 Nov 18.
Cardiovascular disease is a major cause of morbidity and mortality; however, the risks associated with this disease can be reduced by targeting circulating low-density lipoprotein cholesterol (LDL-C) with lipid-lowering drugs, as recommended in many treatment guidelines. Their effectiveness for hypercholesterolemia management depends on appropriate use in at-risk patients. Observational studies have shown varying adherence to national and international guidelines on reaching LDL-C treatment goals.
The Centralized Pan-Middle East Survey on the under-treatment of hypercholesterolemia (CEPHEUS) study observed the current management of hypercholesterolemia in patients on lipid-lowering drugs in seven Middle Eastern countries, and results from 1,043 patients in Egypt are presented here.
Overall, less than 50% of patients achieved their LDL-C treatment goal, with patients at higher risk of a cardiovascular event being less likely to attain their target. Nearly, three-quarters of patients in this study were considered high or very high risk, with only 10% of high-risk patients reaching their treatment goal.
Management of hypercholesterolemia in Egypt is comparatively worse than the average for similar countries in the region, and many patients with high risk of CVD are not being effectively treated. Initiatives to improve physicians' management of these patients and patient compliance to treatment are urgently needed.
AstraZeneca, Cairo, Egypt.
心血管疾病是发病和死亡的主要原因；然而，正如许多治疗指南所推荐的，通过使用降脂药物靶向循环中的低密度脂蛋白胆固醇（LDL-C），可以降低与该疾病相关的风险。它们对高胆固醇血症管理的有效性取决于在高危患者中的恰当使用。观察性研究表明，在实现LDL-C治疗目标方面，对国家和国际指南的遵循情况各不相同。
中东高胆固醇血症治疗不足集中调查（CEPHEUS）研究观察了中东七个国家接受降脂药物治疗的患者目前对高胆固醇血症的管理情况，本文展示了埃及1043例患者的研究结果。
总体而言，不到50%的患者达到了他们的LDL-C治疗目标，心血管事件风险较高的患者达到目标的可能性较小。在这项研究中，近四分之三的患者被认为是高风险或非常高风险，只有10%的高风险患者达到了他们的治疗目标。
埃及高胆固醇血症的管理情况相对该地区类似国家的平均水平较差，许多心血管疾病高风险患者没有得到有效治疗。迫切需要采取举措来改善医生对这些患者的管理以及患者对治疗的依从性。
阿斯利康，埃及开罗
