促成上位性——复杂性状遗传结构中的检测与作用

Capacitating epistasis--detection and role in the genetic architecture of complex traits.

作者信息

Pettersson Mats E, Carlborg Orjan

机构信息

Division of Computational Genetics, Department of Clinical Sciences, Swedish University of Agricultural Sciences, Box 7078, SE-750 07, Uppsala, Sweden.

出版信息

Methods Mol Biol. 2015;1253:185-96. doi: 10.1007/978-1-4939-2155-3_10.

DOI:10.1007/978-1-4939-2155-3_10

PMID:25403533

Abstract

Here, we discuss the potential role of capacitating epistasis in the genetic architecture of complex traits. Two alternative methods for identifying such gene-gene interactions in genetic association studies-mapping of variance controlling loci and the variance plane ratio (VPR) method-are introduced. An overview of the theoretical foundation of the methods is presented together with a discussion on their implementation and available software for performing these analyses. We conclude by highlighting a few examples of capacitating epistasis described in the literature and its potential impacts on the genetics of complex traits.

摘要

在此，我们讨论促成上位性在复杂性状遗传结构中的潜在作用。介绍了在遗传关联研究中识别此类基因-基因相互作用的两种替代方法——方差控制位点映射和方差平面比（VPR）方法。本文概述了这些方法的理论基础，并讨论了它们的实施以及用于执行这些分析的可用软件。我们通过强调文献中描述的一些促成上位性的例子及其对复杂性状遗传学的潜在影响来得出结论。