Maruta A, Matsuzaki M, Fukawa H, Kodama F
Department of Hematology and Chemotherapy, Kanagawa Cancer Center.
Jpn J Antibiot. 1989 Jan;42(1):117-26.
The clinical efficacy of fluconazole at doses of 100-400 mg daily given intravenously in the treatment of 6 cases of deep mycosis complicated with leukemia was evaluated. Types of leukemia as underlying disease were acute lymphatic leukemia in 4 patients (included post bone marrow transplantation in 2 patients), acute myelocytic leukemia in 1 and acute myelomonocytic leukemia (AMMoL) in 1. Causative fungi were Candida in all patients. Diagnoses established were pulmonary or bronchial candidiasis in 3 patients, candiduria in 2 and suspected candidemia accompanied with stomatitis in 1. A patient with candiduria died from AMMoL thus the evaluation of efficacy was made with 5 patients. Overall clinical efficacies were judged to be good in 3 cases of pulmonary or bronchial candidiasis and in 1 case of suspected candidemia accompanied with stomatitis and excellent in 1 case of candiduria with an efficacy rate of 100%. No side effect, either subjective or objective, was reported with any patient. In clinical laboratory tests, elevations of serum transaminase and Al-P were observed in 2 patients and a rise of S-Cr. in 1, but all these abnormalities were judged to be related to the drugs for leukemia treatment.
评估了每日静脉注射100 - 400毫克氟康唑治疗6例白血病合并深部真菌病的临床疗效。作为基础疾病的白血病类型为：4例急性淋巴细胞白血病（其中2例为骨髓移植后），1例急性髓细胞白血病，1例急性粒单核细胞白血病（AMMoL）。所有患者的致病真菌均为念珠菌。确诊为肺部或支气管念珠菌病3例，念珠菌尿2例，疑似念珠菌血症伴口腔炎1例。1例念珠菌尿患者死于AMMoL，因此对5例患者进行了疗效评估。肺部或支气管念珠菌病3例及疑似念珠菌血症伴口腔炎1例的总体临床疗效判定为良好，念珠菌尿1例疗效判定为优秀，有效率为100%。所有患者均未报告主观或客观的副作用。临床实验室检查中，2例患者血清转氨酶和碱性磷酸酶升高，1例血清肌酐升高，但所有这些异常均判定与白血病治疗药物有关。
