Toyama K, Lin K Y, Hojo H, Tsuda A, Torii Y, Yoshikawa O
1st Department of Internal Medicine, Tokyo Medical College.
Jpn J Antibiot. 1989 Jan;42(1):47-54.
The clinical efficacy and the safety of fluconazole as given at an intravenous dose of 100-400 mg daily were assessed in 7 patients with deep mycosis associated with hematological malignancy. Enrolled in the study were 1 patient with acute lymphatic leukemia, 1 with acute myelocytic leukemia, 2 with acute myelomonocytic leukemia, 2 with malignant lymphoma and 1 with myelodysplastic syndrome. Pathogens isolated from 4 patients were all Candida species including 2 Candida albicans, 1 Candida parapsilosis and 1 Candida krusei. Diagnoses of fungal infections of the patients were Candida pneumonia in 3 patients, candidemia in 1 and fungemia suggested in 3. Assessment of the clinical efficacy was made on 4 patients from whom pathogens were isolated. The global clinical improvement was good in 2 patients and fair in 1 with Candida pneumonia and good in 1 with candidemia. In the mycological assessment, pathogenic fungi were eradicated in 3 patients and decreased in 1 patient. No significant adverse reactions nor abnormality in clinical laboratory tests related with the dosing of fluconazole were observed in any of the patients.
对7例与血液系统恶性肿瘤相关的深部真菌病患者评估了每日静脉注射100 - 400毫克氟康唑的临床疗效和安全性。纳入研究的有1例急性淋巴细胞白血病患者、1例急性髓细胞白血病患者、2例急性粒单核细胞白血病患者、2例恶性淋巴瘤患者和1例骨髓增生异常综合征患者。从4例患者中分离出的病原体均为念珠菌属，包括2例白色念珠菌、1例近平滑念珠菌和1例克柔念珠菌。患者的真菌感染诊断为3例念珠菌肺炎、1例念珠菌血症和3例提示真菌血症。对4例分离出病原体的患者进行了临床疗效评估。2例念珠菌肺炎患者整体临床改善良好，1例一般，1例念珠菌血症患者改善良好。在真菌学评估中，3例患者的致病真菌被根除，1例患者的致病真菌数量减少。所有患者均未观察到与氟康唑给药相关的明显不良反应或临床实验室检查异常。
