Oncology (Williston Park). 2014 Nov;28(11):991-1003.
The liver is the most common site of metastases from colorectal cancer. Over the past 3 decades, surgical resection has proved to be the most effective and potentially curative therapy for such metastases. This article will review the current practice of hepatic resection for colorectal liver metastases, including the possibility of combined resection of hepatic metastases at the time of resection of the primary cancer. Effective use of neoadjuvant and adjuvant chemotherapy has further expanded the pool of treatable patients. Most recently, ablative therapies based on needle-delivered thermoablation or radiation therapy have become additional weapons for effective treatment. The relative roles and combined use of these local therapies will be highlighted in this article. Overall, the recent combined advances in surgery, radiation therapy, ablative therapy, and chemotherapy have provided more patients with a chance for long-term survival.
肝脏是结直肠癌转移的最常见部位。在过去的 30 年中，手术切除已被证明是治疗此类转移的最有效和潜在的治愈方法。本文将回顾目前用于结直肠癌肝转移的肝切除术，包括在切除原发性癌症时联合切除肝转移的可能性。新辅助和辅助化疗的有效应用进一步扩大了可治疗患者的范围。最近，基于针输送的热消融或放射治疗的消融疗法已成为有效治疗的附加手段。本文将重点介绍这些局部治疗方法的相对作用和联合应用。总的来说，最近在手术、放射治疗、消融治疗和化疗方面的综合进展为更多患者提供了长期生存的机会。
