文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

二烯丙基三硫化物抑制人结肠癌HT - 29细胞和人脐静脉内皮细胞的迁移、侵袭和血管生成，并抑制小鼠异种移植瘤的生长。

Diallyl trisulfide inhibits migration, invasion and angiogenesis of human colon cancer HT-29 cells and umbilical vein endothelial cells, and suppresses murine xenograft tumour growth.

作者信息

Lai Kuang-Chi, Hsu Shu-Chun, Yang Jai-Sing, Yu Chien-Chih, Lein Jin-Cherng, Chung Jing-Gung

机构信息

Department of Surgery, China Medical University Beigang Hospital, Yunlin, Taiwan; School of Medicine, China Medical University, Taichung, Taiwan.

出版信息

J Cell Mol Med. 2015 Feb;19(2):474-84. doi: 10.1111/jcmm.12486. Epub 2014 Nov 17.

DOI:10.1111/jcmm.12486
PMID:25403643
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4407594/
Abstract

Angiogenesis inhibitors are beneficial for the prevention and treatment of angiogenesis-dependent diseases including cancer. We examined the cytotoxic, anti-metastatic, anti-cancer and anti-angiogenic effects of diallyl trisulfide (DATS). In HT29 cells, DATS inhibited migration and invasion through the inhibition of focal adhesion kinase (FAK), extracellular signal-regulated kinase, c-Jun N-terminal kinase and p38 which was associated with inhibition of matrix metalloproteinases-2, -7 and -9 and VEGF. In human umbilical vein endothelial cells (HUVEC), DATS inhibited the migration and angiogenesis through FAK, Src and Ras. DATS also inhibited the secretion of VEGF. The capillary-like tube structure formation and migration by HUVEC was inhibited by DATS. The chicken egg chorioallantoic membrane (CAM) assay indicated that DATS treatment inhibited ex-vivo angiogenesis. We investigated the anti-tumour effects of DATS against human colon cancer xenografts in BALB/c(nu/nu) mice and its anti-angiogenic activity in vivo. In this in-vivo study, DATS also inhibited the tumour growth, tumour weight and angiogenesis (decreased the levels of haemoglobin) in HT29 cells. In conclusion, the present results suggest that the inhibition of angiogenesis may be an important mechanism in colon cancer chemotherapy by DATS.

摘要

血管生成抑制剂对预防和治疗包括癌症在内的血管生成依赖性疾病有益。我们研究了二烯丙基三硫化物（DATS）的细胞毒性、抗转移、抗癌和抗血管生成作用。在HT29细胞中，DATS通过抑制粘着斑激酶（FAK）、细胞外信号调节激酶、c-Jun氨基末端激酶和p38来抑制迁移和侵袭，这与抑制基质金属蛋白酶-2、-7和-9以及血管内皮生长因子（VEGF）有关。在人脐静脉内皮细胞（HUVEC）中，DATS通过FAK、Src和Ras抑制迁移和血管生成。DATS还抑制VEGF的分泌。DATS抑制了HUVEC的毛细血管样管结构形成和迁移。鸡胚绒毛尿囊膜（CAM）试验表明，DATS处理抑制了体外血管生成。我们研究了DATS对BALB/c（nu/nu）小鼠人结肠癌异种移植瘤的抗肿瘤作用及其体内抗血管生成活性。在这项体内研究中，DATS还抑制了HT29细胞的肿瘤生长、肿瘤重量和血管生成（降低血红蛋白水平）。总之，目前的结果表明，抑制血管生成可能是DATS进行结肠癌化疗的重要机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fff5/4407594/4419d8dc26e1/jcmm0019-0474-f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fff5/4407594/59f1eed331bb/jcmm0019-0474-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fff5/4407594/fe006bcd26ab/jcmm0019-0474-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fff5/4407594/87cf0147f8e5/jcmm0019-0474-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fff5/4407594/040936b3d646/jcmm0019-0474-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fff5/4407594/d324372dec0a/jcmm0019-0474-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fff5/4407594/0696ef5269dd/jcmm0019-0474-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fff5/4407594/83261134452b/jcmm0019-0474-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fff5/4407594/0cbaca8dfef7/jcmm0019-0474-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fff5/4407594/4419d8dc26e1/jcmm0019-0474-f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fff5/4407594/59f1eed331bb/jcmm0019-0474-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fff5/4407594/fe006bcd26ab/jcmm0019-0474-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fff5/4407594/87cf0147f8e5/jcmm0019-0474-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fff5/4407594/040936b3d646/jcmm0019-0474-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fff5/4407594/d324372dec0a/jcmm0019-0474-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fff5/4407594/0696ef5269dd/jcmm0019-0474-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fff5/4407594/83261134452b/jcmm0019-0474-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fff5/4407594/0cbaca8dfef7/jcmm0019-0474-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fff5/4407594/4419d8dc26e1/jcmm0019-0474-f9.jpg

相似文献

[1]
Diallyl trisulfide inhibits migration, invasion and angiogenesis of human colon cancer HT-29 cells and umbilical vein endothelial cells, and suppresses murine xenograft tumour growth.

J Cell Mol Med. 2015-2

[2]
Diallyl trisulfide inhibits angiogenic features of human umbilical vein endothelial cells by causing Akt inactivation and down-regulation of VEGF and VEGF-R2.

Nutr Cancer. 2006

[3]
Diallyl trisulfide suppresses growth of PC-3 human prostate cancer xenograft in vivo in association with Bax and Bak induction.

Clin Cancer Res. 2006-11-15

[4]
Diallyl trisulfide inhibits proliferation, invasion and angiogenesis of osteosarcoma cells by switching on suppressor microRNAs and inactivating of Notch-1 signaling.

Carcinogenesis. 2013-2-20

[5]
Ursolic acid inhibits colorectal cancer angiogenesis through suppression of multiple signaling pathways.

Int J Oncol. 2013-9-16

[6]
Diallyl sulfide, diallyl disulfide, and diallyl trisulfide inhibit migration and invasion in human colon cancer colo 205 cells through the inhibition of matrix metalloproteinase-2, -7, and -9 expressions.

Environ Toxicol. 2011-6-21

[7]
Impact of ER520, a candidate of selective estrogen receptor modulators, on in vitro cell growth, migration, invasion, angiogenesis and in vivo tumor xenograft of human breast cancer cells.

Cancer Chemother Pharmacol. 2015-12

[8]
Barbigerone, an isoflavone, inhibits tumor angiogenesis and human non-small-cell lung cancer xenografts growth through VEGFR2 signaling pathways.

Cancer Chemother Pharmacol. 2012-7-20

[9]
Antiangiogenic mechanisms of PJ-8, a novel inhibitor of vascular endothelial growth factor receptor signaling.

Carcinogenesis. 2012-3-20

[10]
Inhibition of angiogenesis involves in anticancer activity of riccardin D, a macrocyclic bisbibenzyl, in human lung carcinoma.

Eur J Pharmacol. 2011-6-23

引用本文的文献

[1]
Targeting the major pro-inflammatory interleukin-6-type cytokine receptor gp130 by antagonistic single domain antibodies.

Front Immunol. 2025-8-15

[2]
Zebrafish xenograft as a tool for the study of colorectal cancer: a review.

Cell Death Dis. 2024-1-9

[3]
Potential antitumor activity of garlic against colorectal cancer: focus on the molecular mechanisms of action.

Eur J Nutr. 2023-9

[4]
Involvement of adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 in diallyl trisulfide-induced cytotoxicity in hepatocellular carcinoma cells.

Korean J Physiol Pharmacol. 2022-11-1

[5]
Diallyl disulfide and diallyl trisulfide in garlic as novel therapeutic agents to overcome drug resistance in breast cancer.

J Pharm Anal. 2022-4

[6]
Tetrandrine Enhances HO-Induced Apoptotic Cell Death Through Caspase-dependent Pathway in Human Keratinocytes.

In Vivo. 2021

[7]
Roles of Nrf2 in Gastric Cancer: Targeting for Therapeutic Strategies.

Molecules. 2021-5-25

[8]
Diallyl thiosulfinate enhanced the anti-cancer activity of dexamethasone in the side population cells of multiple myeloma by promoting miR-127-3p and deactivating the PI3K/AKT signaling pathway.

BMC Cancer. 2021-2-6

[9]
Role of hydrogen sulfide donors in cancer development and progression.

Int J Biol Sci. 2021

[10]
Diallyl trisulfide regulates cell apoptosis and invasion in human osteosarcoma U2OS cells through regulating PI3K/AKT/GSK3β signaling pathway.

Histol Histopathol. 2020-12

本文引用的文献

[1]
Danthron, an anthraquinone derivative, induces DNA damage and caspase cascades-mediated apoptosis in SNU-1 human gastric cancer cells through mitochondrial permeability transition pores and Bax-triggered pathways.

Chem Res Toxicol. 2010-12-2

[2]
The flavonol isorhamnetin exhibits cytotoxic effects on human colon cancer cells.

J Agric Food Chem. 2010-10-27

[3]
New advances on critical implications of tumor- and metastasis-initiating cells in cancer progression, treatment resistance and disease recurrence.

Histol Histopathol. 2010-8

[4]
Inflammation and cancer: a multifaceted link.

Eur Rev Med Pharmacol Sci. 2010-4

[5]
Curcumin enhances dasatinib-induced inhibition of growth and transformation of colon cancer cells.

Int J Cancer. 2011-2-15

[6]
MJ-29 inhibits tubulin polymerization, induces mitotic arrest, and triggers apoptosis via cyclin-dependent kinase 1-mediated Bcl-2 phosphorylation in human leukemia U937 cells.

J Pharmacol Exp Ther. 2010-5-12

[7]
Antiangiogenic activity of ursolic acid.

Integr Cancer Ther. 2010-5-11

[8]
[Therapeutic angiogenesis for diabetes mellitus related ischemic disease].

Nihon Rinsho. 2010-5

[9]
Serum vascular endothelial growth factor and adiponectin levels in patients with benign and malignant gynecological diseases.

Int J Gynecol Cancer. 2010-5

[10]
Vascular endothelial growth factor and epidermal growth factor signaling pathways as therapeutic targets for colorectal cancer.

Gastroenterology. 2010-6

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索