Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng, Henan 475004, China.
Department of Biological Sciences, Faculty of Science, Dar es Salaam University College of Education, Dar es Salaam 2329, Tanzania.
Int J Biol Sci. 2021 Jan 1;17(1):73-88. doi: 10.7150/ijbs.47850. eCollection 2021.
In recent years, a vast number of potential cancer therapeutic targets have emerged. However, developing efficient and effective drugs for the targets is of major concern. Hydrogen sulfide (HS), one of the three known gasotransmitters, is involved in the regulation of various cellular activities such as autophagy, apoptosis, migration, and proliferation. Low production of HS has been identified in numerous cancer types. Treating cancer cells with HS donors is the common experimental technique used to improve HS levels; however, the outcome depends on the concentration/dose, time, cell type, and sometimes the drug used. Both natural and synthesized donors are available for this purpose, although their effects vary independently ranging from strong cancer suppressors to promoters. Nonetheless, numerous signaling pathways have been reported to be altered following the treatments with HS donors which suggest their potential in cancer treatment. This review will analyze the potential of HS donors in cancer therapy by summarizing key cellular processes and mechanisms involved.
近年来，出现了大量潜在的癌症治疗靶点。然而，开发针对这些靶点的高效药物是主要关注点。硫化氢（HS）是三种已知气体递质之一，参与调节自噬、凋亡、迁移和增殖等各种细胞活动。在许多癌症类型中，HS 的产生量较低。用 HS 供体处理癌细胞是常用的实验技术，用于提高 HS 水平；然而，结果取决于浓度/剂量、时间、细胞类型，有时还取决于所用的药物。天然和合成供体均可用于此目的，尽管它们的作用独立变化，从强烈的癌症抑制剂到促进剂不等。尽管如此，据报道，HS 供体处理后，许多信号通路发生改变，这表明它们在癌症治疗中的潜力。本综述通过总结涉及的关键细胞过程和机制，分析 HS 供体在癌症治疗中的潜力。
