Song Geng-Qing, Zhu Hongbing, Lei Yong, Yuan Charlene, Starkebaum Warren, Yin Jieyun, Chen Jiande D Z
Veterans Research and Education Foundation, VA Medical Center, Oklahoma City, OK, USA.
Obes Surg. 2015 Jun;25(6):1047-55. doi: 10.1007/s11695-014-1491-8.
The aim of this study was to test the hypothesis that that a method of gastric electrical stimulation (GES) optimized to inhibit gastric motility was effective in reducing food intake in dogs.
Female dogs with a gastric cannula and gastric serosal electrodes were studied in three experiments: (1) to determine the best parameters and locations of GES in inhibiting gastric tone, slow waves, and contractions in dogs;( 2) to investigate the reproducibility of the inhibitory effects of GES; and (3) to study the effect of the GES method on food intake in dogs.
(1) For GES to exert significant effects on gastric motility, a pulse width of ≥2 ms was required, and with other appropriate inhibitory parameters, GES was able to increase gastric volume by 190.4 %, reduce antral contractions by 39.7 %, and decrease the percentage of normal slow waves by 47.6 %. In addition, the inhibitory effect of GES was more potent with the stimulation electrodes placed along the lesser or greater curvature than placed in the middle, and more potent with the electrodes placed in the distal stomach than in the proximal stomach; (2) the inhibitory effects of GES on gastric motility were reproducible; (3) the GES method optimized to inhibit gastric motility produced a 20 % reduction in food intakes in non-obese dogs.
GES with appropriate parameters inhibits gastric motility, and the effects are reproducible. The GES method optimized to inhibit gastric motility reduces food intake in healthy dogs and may have a therapeutic potential for treating obesity.
本研究旨在验证以下假设，即一种经优化以抑制胃动力的胃电刺激（GES）方法可有效减少犬类的食物摄入量。
对带有胃插管和胃浆膜电极的雌性犬进行了三项实验：（1）确定GES抑制犬胃张力、慢波和收缩的最佳参数及位置；（2）研究GES抑制作用的可重复性；（3）研究GES方法对犬食物摄入量的影响。
（1）为使GES对胃动力产生显著影响，所需脉冲宽度≥2毫秒，在其他合适的抑制参数下，GES能够使胃容量增加190.4%，使胃窦收缩减少39.7%，并使正常慢波百分比降低47.6%。此外，将刺激电极沿胃小弯或胃大弯放置时，GES的抑制作用比放置在胃中部时更强，且电极放置在胃远端时比放置在胃近端时的抑制作用更强；（2）GES对胃动力的抑制作用具有可重复性；（3）经优化以抑制胃动力的GES方法使非肥胖犬的食物摄入量减少了20%。
具有适当参数的GES可抑制胃动力，且效果具有可重复性。经优化以抑制胃动力的GES方法可减少健康犬的食物摄入量，可能具有治疗肥胖症的潜力。
